Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials

Jhalok Ronjan Talukdar; Matthew Adam Cooper; Lyuba Lyutvyn; Dena Zeraatkar; Rahim Ali; Rachel Bierbrier; Sabrina Janes; Vanessa Ha; Pauline B Darling; John L Sievenpiper; David J A Jenkins; Laura Banfield; Lawrence Mbuagbaw; Russell J de Souza

doi:10.1136/bmjopen-2021-058875

Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials

BMJ Open. 2022 Jul 6;12(7):e058875. doi: 10.1136/bmjopen-2021-058875.

Authors

Jhalok Ronjan Talukdar¹, Matthew Adam Cooper², Lyuba Lyutvyn¹, Dena Zeraatkar^{1

3}, Rahim Ali⁴, Rachel Bierbrier⁵, Sabrina Janes⁶, Vanessa Ha⁷, Pauline B Darling⁸, John L Sievenpiper^{9

10}, David J A Jenkins^{9

10

11}, Laura Banfield¹², Lawrence Mbuagbaw^{1

13

14

15

16

17}, Russell J de Souza^{18

19

20}

Affiliations

¹ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
² Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
³ Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
⁴ Faculty of Law (Common Law Section), University of Ottawa, Ottawa, Ontario, Canada.
⁵ Department of Dermatology, McGill University Health Centre, Montreal, Québec, Canada.
⁶ St Michael's Hospital, Toronto, Ontario, Canada.
⁷ School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.
⁸ School of Nutrition Sciences, University of Ottawa, Ottawa, Ontario, Canada.
⁹ Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
¹⁰ Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
¹¹ Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
¹² Health Sciences Library, McMaster University, Hamilton, Ontario, Canada.
¹³ Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
¹⁴ Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, Ontario, Canada.
¹⁵ Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
¹⁶ Centre for Development of Best Practices in Health (CDBPH), Yaoundé Central Hospital, Yaoundé, Cameroon.
¹⁷ Department of Global Health, Stellenbosch University, Cape Town, South Africa.
¹⁸ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada [email protected].
¹⁹ Global Health Graduate Program, McMaster University, Hamilton, Ontario, Canada.
²⁰ Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada.

Abstract

Introduction: This review aims to assess the effects of dietary supplementation with inulin-type fructans (ITF) compared with no supplementation on cardiovascular disease risk factors in adults and assess the quality of trial reporting using the Consolidated Standards of Reporting Trials (CONSORT) and CONSORT for abstract (CONSORT-A) checklists.

Methods and analysis: We will search randomised controlled trials (RCTs) in MEDLINE, EMBASE, CINAHL, Emcare, AMED and the Cochrane Database of Systematic Reviews from inception to 31 March 2022, without any language restrictions. The RCTs need to administer ITF in adults for at least 2 weeks and assess effects on at least one cardiovascular risk factor. We will exclude RCTs that (1) assessed the postprandial effects of ITF; (2) included pregnant or lactating participants; (3) enrolled participants undergoing treatment that might affect the response to ITF. We will assess the study risk of bias (RoB) using V.2 of the Cochrane RoB tool for RCTs (RoB 2) and the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We will pool data using a random-effects model. We will use the χ² test to compare compliance of CONSORT and CONSORT-A checklists and Poisson regression to identify factors associated with better reporting.

Ethics and dissemination: Ethics approval is not required for secondary analysis of already published data. We will publish the reviews in a peer-review journal.

Prospero registration number: CRD42019136745.

Keywords: coronary heart disease; ischaemic heart disease; nutrition.

MeSH terms

Adult
Cardiovascular Diseases* / prevention & control
Fructans* / pharmacology
Fructans* / therapeutic use
Humans
Inulin
Meta-Analysis as Topic
Randomized Controlled Trials as Topic
Systematic Reviews as Topic

Substances

Fructans
Inulin