Coordinating gene expression during the cell cycle

Martin Fischer; Amy E Schade; Timothy B Branigan; Gerd A Müller; James A DeCaprio

doi:10.1016/j.tibs.2022.06.007

Coordinating gene expression during the cell cycle

Trends Biochem Sci. 2022 Dec;47(12):1009-1022. doi: 10.1016/j.tibs.2022.06.007. Epub 2022 Jul 11.

Authors

Martin Fischer¹, Amy E Schade², Timothy B Branigan³, Gerd A Müller⁴, James A DeCaprio⁵

Affiliations

¹ Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745, Jena, Germany. Electronic address: [email protected].
² Genetics Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
³ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
⁴ Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
⁵ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 35835684
DOI: 10.1016/j.tibs.2022.06.007

Abstract

Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin-dependent kinase (CDK) phosphorylation of RB and DREAM allows for the expression of two gene sets. The first set of genes, with peak expression in G1/S, is activated by E2F transcription factors (TFs) and is required for DNA synthesis. The second set, with maximum expression during G2/M, is required for mitosis and is coordinated by the MuvB complex, together with B-MYB and Forkhead box M1 (FOXM1). In this review, we summarize the key findings that established the distinct control mechanisms regulating G1/S and G2/M gene expression in mammals and discuss recent advances in the understanding of the temporal control of these genes.

Keywords: B-MYB; DREAM complex; FOXM1; MuvB complex; RB:E2F complex; transcription factors.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Cycle / genetics
Cell Cycle Proteins* / metabolism
Cyclin-Dependent Kinases / genetics
Gene Expression
Mammals
Mitosis
Repressor Proteins* / genetics

Substances

Repressor Proteins
Cell Cycle Proteins
Cyclin-Dependent Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding