Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives

Blood Rev. 2023 Jan:57:100996. doi: 10.1016/j.blre.2022.100996. Epub 2022 Aug 2.

Abstract

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in clonal proliferation of abnormally differentiated hematopoietic cells. In this review, mechanisms contributing to myeloid leukemogenesis are summarized, highlighting aberrations of epigenetics, transcription factors, signal transduction, cell cycling, and the bone marrow microenvironment. The mechanisms contributing to AML are detailed to spotlight recent findings that convey clinical impact. The applications of current and prospective therapeutic targets are accentuated in addition to reviews of treatment paradigms stratified for each characteristic molecular lesion - with a focus on exploring novel treatment approaches and combinations to improve outcomes in AML.

Keywords: Acute myeloid leukemia; Cell cycle; Epigenetics; Leukemogenesis; Novel strategies; Oncoprotein; Signal transduction; Targeted therapy; Transcription factor.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Marrow
  • Epigenesis, Genetic
  • Humans
  • Leukemia, Myeloid, Acute* / drug therapy
  • Leukemia, Myeloid, Acute* / therapy
  • Signal Transduction
  • Transcription Factors
  • Tumor Microenvironment

Substances

  • Transcription Factors