Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia

Yang Song; Qiuyun Fang; Yingchang Mi

doi:10.3389/fonc.2022.981036

Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia

Front Oncol. 2022 Aug 4:12:981036. doi: 10.3389/fonc.2022.981036. eCollection 2022.

Authors

Yang Song¹, Qiuyun Fang¹, Yingchang Mi¹

Affiliation

¹ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Abstract

Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personalized management of this population. The discovery of the molecular mechanism of gene deletion and the development of targeted drugs will further enhance the clinical prognosis of B-ALL.

Keywords: CDKN2A/2B deletion; IKZF1 deletion; PAX5 deletion; acute lymphoblastic leukemia; copy number variation; gene deletion; prognosis.

Publication types

Review