Cationic gold(I)-catalyzed glycosylation with glycosyl N-1,1-dimethylpropargyl carbamate donors

Org Biomol Chem. 2022 Sep 14;20(35):7006-7010. doi: 10.1039/d2ob01436j.

Abstract

A mild and efficient cationic gold(I)-catalyzed O-glycosylation methodology involving the use of bench-stable glycosyl N-1,1-dimethylpropargyl carbamate donors has been developed. In the presence of 1-2 mol% [tris(2,4-di-tert-butylphenyl)phosphite]gold(I) chloride and 5 mol% silver triflate, both "armed" and "disarmed" glycosyl N-1,1-dimethylpropargyl carbamate donors react with various sugar acceptors at room temperature to afford the corresponding glycosides in good to excellent yields. These glycosyl N-1,1-dimethylpropargyl carbamates are found to be orthogonal to regular phenyl thioglycoside donors. The utilization of this method has been demonstrated in the synthesis of a trisaccharide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbamates*
  • Catalysis
  • Cations
  • Glycosides
  • Glycosylation
  • Gold*

Substances

  • Carbamates
  • Cations
  • Glycosides
  • Gold