Point mutation L116R in interferon-regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells

Eur J Immunol. 2022 Oct;52(10):1680-1683. doi: 10.1002/eji.202249869. Epub 2022 Sep 19.

Abstract

IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of Th9 cells in cells carrying the L116R mutated IRF4.

Keywords: IRF4; T-cell-differentiation; cytokine; interleukin; point mutation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / genetics
  • Cytokines / genetics
  • Cytokines / metabolism
  • Interferon Regulatory Factors / genetics
  • Interferon Regulatory Factors / metabolism
  • Interferons / genetics
  • Interleukin-9* / genetics
  • Interleukin-9* / metabolism
  • Point Mutation
  • Th17 Cells* / metabolism
  • Th2 Cells / metabolism

Substances

  • Cytokines
  • Interferon Regulatory Factors
  • Interleukin-9
  • Interferons