One hundred twenty-six patients with the diagnosis of lymphoma underwent staging with both lymphangiography and computed tomography (CT) of the abdomen and pelvis. These patients were retrospectively studied to determine the optimal imaging modality for follow-up. Six hundred seventy-four CT scans were correlated with 138 lymphangiograms and 840 follow-up KUB (kidney, ureter, bladder) radiographs. In 21 patients there was evidence of relapse, and in 105 the disease had regressed or remained stable. In all patients with evidence of progression or regression on the CT scan, there was a concomitant change in opacified lymph nodes on the KUB radiographs. It is recommended that the initial staging of lymphoma be done with lymphangiography and CT. If the findings of both are positive, then follow-up should consist of only KUB radiography. If progression is detected, restaging with CT may also be performed. This approach will not only reduce the radiation dose but will also save time and money and enable a more efficient use of radiologic equipment.