Rectal organoid-guided CFTR modulator therapy restores lung function in a cystic fibrosis patient with the rare 1677delTA/R334W genotype

Affiliations

• ¹ Adult Cystic Fibrosis and CFTR-related disorders Center, Division of Pulmonology, Dept of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland [email protected].
• ² Lung Transplant Center, Division of Pulmonology, Dept of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
• ³ Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology, Lausanne, Switzerland.
• ⁴ SUN bioscience, EPFL Innovation Park, Lausanne, Switzerland.
• ⁵ Adult Cystic Fibrosis and CFTR-related disorders Center, Division of Pulmonology, Dept of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
• ⁶ Paediatric Pulmonology and Cystic Fibrosis Unit, Division of Paediatrics, Dept Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
• ⁷ Division of Gastro-enterology, Dept of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
• ⁸ Division of Pulmonology, Dept of Medicine, Neuchâtel Hospital Network, Neuchâtel, Switzerland.
• ⁹ These authors contributed equally.