Detection and Monitoring of Circulating Tumor HPV DNA in HPV-Associated Sinonasal and Nasopharyngeal Cancers

Saskia Naegele; Vasileios Efthymiou; Dipon Das; Peter M Sadow; Jeremy D Richmon; A John Iafrate; Daniel L Faden

doi:10.1001/jamaoto.2022.4107

Detection and Monitoring of Circulating Tumor HPV DNA in HPV-Associated Sinonasal and Nasopharyngeal Cancers

JAMA Otolaryngol Head Neck Surg. 2023 Feb 1;149(2):179-181. doi: 10.1001/jamaoto.2022.4107.

Authors

Saskia Naegele¹, Vasileios Efthymiou¹, Dipon Das^{1

2}, Peter M Sadow^{1

2

3}, Jeremy D Richmon^{1

2}, A John Iafrate^{2

3

4}, Daniel L Faden^{1

2

5}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, Massachusetts.
² Harvard Medical School, Boston, Massachusetts.
³ Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
⁴ Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
⁵ Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

No abstract available

Plain language summary

This prospective observational study examines if circulating tumor human papillomavirus DNA can be used as an accurate measure of disease status at the time of diagnosis, throughout treatment, and during monitoring in human papillomavirus-associated sinonasal and nasopharyngeal squamous cell carcinomas.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Carcinoma, Squamous Cell* / pathology
DNA
DNA, Viral / genetics
Humans
Nasopharyngeal Neoplasms*
Papillomaviridae / genetics
Papillomavirus Infections* / complications
Papillomavirus Infections* / diagnosis
Papillomavirus Infections* / pathology
Paranasal Sinus Neoplasms* / pathology

Substances

DNA
DNA, Viral

Plain language summary

Publication types

MeSH terms

Substances

Grants and funding