GATOR2 rings GATOR1 to speak to mTORC1

Umakant Sahu; Issam Ben-Sahra

doi:10.1016/j.molcel.2022.12.011

GATOR2 rings GATOR1 to speak to mTORC1

Mol Cell. 2023 Jan 5;83(1):6-8. doi: 10.1016/j.molcel.2022.12.011.

Authors

Umakant Sahu¹, Issam Ben-Sahra²

Affiliations

¹ Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
² Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address: [email protected].

Abstract

The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.

Publication types

Research Support, N.I.H., Extramural
Kommentar

MeSH terms

Leucine
Lysosomes
Mechanistic Target of Rapamycin Complex 1 / genetics
Multiprotein Complexes* / genetics
TOR Serine-Threonine Kinases* / genetics

Substances

Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases
Multiprotein Complexes
Leucine

Abstract

Publication types

MeSH terms

Substances

Grants and funding