Decreasing Incidence of the Multisystem Inflammatory Syndrome in Children Over 3 Pandemic Waves

Pediatr Infect Dis J. 2023 Feb 1;42(2):122-124. doi: 10.1097/INF.0000000000003766. Epub 2022 Nov 7.

Abstract

In this nationwide retrospective study, a substantial decline in the incidence of multisystem inflammatory syndrome in children over 3 successive pandemic waves characterized by different severe acute respiratory syndrome coronavirus 2 variants was documented-from 3.4 of 1000 to 1.1 of 1000 and finally to 0.25 of 1000 confirmed severe acute respiratory syndrome coronavirus 2 positive cases (P < 0.0001), respectively, whereas clinical findings and severity did not significantly vary.

MeSH terms

  • COVID-19* / epidemiology
  • Child
  • Humans
  • Incidence
  • Pandemics
  • Retrospective Studies
  • SARS-CoV-2*
  • Systemic Inflammatory Response Syndrome / epidemiology

Supplementary concepts

  • SARS-CoV-2 variants
  • pediatric multisystem inflammatory disease, COVID-19 related