Nanoparticle: A Promising Player in Nanomedicine and its Theranostic Applications for the Treatment of Cardiovascular Diseases

Sumbul Saeed; Syed Riaz Ud Din; Shahid Ullah Khan; Rukhsana Gul; Faisal Ayub Kiani; Abdul Wahab; Mintao Zhong

doi:10.1016/j.cpcardiol.2023.101599

Nanoparticle: A Promising Player in Nanomedicine and its Theranostic Applications for the Treatment of Cardiovascular Diseases

Curr Probl Cardiol. 2023 May;48(5):101599. doi: 10.1016/j.cpcardiol.2023.101599. Epub 2023 Jan 18.

Authors

Sumbul Saeed¹, Syed Riaz Ud Din², Shahid Ullah Khan³, Rukhsana Gul⁴, Faisal Ayub Kiani⁵, Abdul Wahab⁶, Mintao Zhong⁷

Affiliations

¹ National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: [email protected].
² Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, P.R China. Electronic address: [email protected].
³ Women Medical and Dental College, Khyber Medical University, Khyber Pakhtunkhwa, Pakistan.
⁴ Department of Chemistry, Kohat University of Science and Technology, Khyber Pakhtunkhwa, Pakistan.
⁵ Department of Clinical Sciences, Faculty of Veterinary Sciences, Bahauddin Zakariyah University, Multan, 60800, Pakistan. Electronic address: [email protected].
⁶ Department of Pharmacy, Kohat University of Science and Technology, Kohat, Khyber Pakhtunkhwa, Pakistan. Electronic address: [email protected].
⁷ Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, P.R China. Electronic address: [email protected].

PMID: 36681209
DOI: 10.1016/j.cpcardiol.2023.101599

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death around the world, a trend that will progressively grow over the next decade. Recently, with the advancement of nanotechnology, innovative nanoparticles (NPs) have been efficiently utilized in disease diagnosis and theranostic applications. In this review, we highlighted the benchmark summary of the recently synthesized NPs that are handy for imaging, diagnosis, and treatment of CVDs. NPs are the carrier of drug-delivery payloads actively reaching more areas of the heart and arteries, allowing them novel therapeutic agents for CVDs. Herein, due to the limited availability of literature, we only focused on NPs mechanism in the cardiovascular system and various treatment-based approaches that opens a new window for future research and versatile approach in the field of medical and clinical applications. Moreover, current challenges and limitations for the detection of CVDs has also discussed.

Publication types

Review

MeSH terms

Cardiovascular Diseases* / drug therapy
Cardiovascular Diseases* / therapy
Diagnostic Imaging
Humans
Nanomedicine / methods
Nanoparticles* / therapeutic use
Precision Medicine