Advanced MR Techniques for Preoperative Glioma Characterization: Part 2

Gilbert Hangel; Bárbara Schmitz-Abecassis; Nico Sollmann; Joana Pinto; Fatemehsadat Arzanforoosh; Frederik Barkhof; Thomas Booth; Marta Calvo-Imirizaldu; Guilherme Cassia; Marek Chmelik; Patricia Clement; Ece Ercan; Maria A Fernández-Seara; Julia Furtner; Elies Fuster-Garcia; Matthew Grech-Sollars; N Tugay Guven; Gokce Hale Hatay; Golestan Karami; Vera C Keil; Mina Kim; Johan A F Koekkoek; Simran Kukran; Laura Mancini; Ruben Emanuel Nechifor; Alpay Özcan; Esin Ozturk-Isik; Senol Piskin; Kathleen M Schmainda; Siri F Svensson; Chih-Hsien Tseng; Saritha Unnikrishnan; Frans Vos; Esther Warnert; Moss Y Zhao; Radim Jancalek; Teresa Nunes; Lydiane Hirschler; Marion Smits; Jan Petr; Kyrre E Emblem

doi:10.1002/jmri.28663

Advanced MR Techniques for Preoperative Glioma Characterization: Part 2

J Magn Reson Imaging. 2023 Jun;57(6):1676-1695. doi: 10.1002/jmri.28663. Epub 2023 Mar 13.

Authors

Gilbert Hangel^{1

2

3

4}, Bárbara Schmitz-Abecassis^{5

6}, Nico Sollmann^{7

8

9}, Joana Pinto¹⁰, Fatemehsadat Arzanforoosh¹¹, Frederik Barkhof^{12

13}, Thomas Booth^{14

15}, Marta Calvo-Imirizaldu¹⁶, Guilherme Cassia¹⁷, Marek Chmelik¹⁸, Patricia Clement^{19

20}, Ece Ercan⁵, Maria A Fernández-Seara^{16

21}, Julia Furtner^{22

23}, Elies Fuster-Garcia²⁴, Matthew Grech-Sollars^{25

26}, N Tugay Guven²⁷, Gokce Hale Hatay²⁷, Golestan Karami¹⁴, Vera C Keil^{12

28}, Mina Kim²⁹, Johan A F Koekkoek^{30

31}, Simran Kukran^{32

33}, Laura Mancini^{26

34}, Ruben Emanuel Nechifor³⁵, Alpay Özcan³⁶, Esin Ozturk-Isik²⁷, Senol Piskin³⁷, Kathleen M Schmainda³⁸, Siri F Svensson^{39

40}, Chih-Hsien Tseng^{6

41}, Saritha Unnikrishnan^{42

43}, Frans Vos^{6

11

41}, Esther Warnert¹¹, Moss Y Zhao^{44

45}, Radim Jancalek^{46

47}, Teresa Nunes⁴⁸, Lydiane Hirschler⁴⁹, Marion Smits^{6

11

50}, Jan Petr⁵¹, Kyrre E Emblem³⁹

Affiliations

¹ Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
² High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
³ Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria.
⁴ Medical Imaging Cluster, Medical University of Vienna, Vienna, Austria.
⁵ Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
⁶ Medical Delta Foundation, Delft, the Netherlands.
⁷ Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany.
⁸ Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
⁹ TUM-Neuroimaging Center, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
¹⁰ Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
¹¹ Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands.
¹² Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands.
¹³ Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK.
¹⁴ School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
¹⁵ Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, UK.
¹⁶ Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain.
¹⁷ Rede D'Or São Luiz, Hospital Santa Luzia, Brazil.
¹⁸ Department of Technical Disciplines in Medicine, Faculty of Health Care, University of Prešov, Prešov, Slovakia.
¹⁹ Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
²⁰ Department of Medical Imaging, Ghent University Hospital, Ghent, Belgium.
²¹ IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
²² Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
²³ Research Center of Medical Image Analysis and Artificial Intelligence, Danube Private University, Austria.
²⁴ Biomedical Data Science Laboratory, Instituto Universitario de Tecnologías de la Información y Comunicaciones, Universitat Politècnica de València, Valencia, Spain.
²⁵ Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
²⁶ Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.
²⁷ Institute of Biomedical Engineering, Bogazici University Istanbul, Istanbul, Turkey.
²⁸ Cancer Center Amsterdam, Amsterdam, Netherlands.
²⁹ Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering and Department of Neuroinflammation, University College London, London, UK.
³⁰ Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.
³¹ Department of Neurology, Haaglanden Medical Center, Netherlands.
³² Department of Bioengineering, Imperial College London, London, UK.
³³ Department of Radiotherapy and Imaging, Institute of Cancer Research, UK.
³⁴ Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK.
³⁵ Department of Clinical Psychology and Psychotherapy, International Institute for the Advanced Studies of Psychotherapy and Applied Mental Health, Babes-Bolyai University, Romania.
³⁶ Electrical and Electronics Engineering Department, Bogazici University Istanbul, Istanbul, Turkey.
³⁷ Department of Mechanical Engineering, Faculty of Natural Sciences and Engineering, Istinye University Istanbul, Istanbul, Turkey.
³⁸ Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
³⁹ Department of Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway.
⁴⁰ Department of Physics, University of Oslo, Oslo, Norway.
⁴¹ Department of Imaging Physics, Delft University of Technology, Delft, the Netherlands.
⁴² Faculty of Engineering and Design, Atlantic Technological University (ATU) Sligo, Sligo, Ireland.
⁴³ Mathematical Modelling and Intelligent Systems for Health and Environment (MISHE), ATU Sligo, Sligo, Ireland.
⁴⁴ Department of Radiology, Stanford University, Stanford, California, USA.
⁴⁵ Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.
⁴⁶ Department of Neurosurgery, St. Anne's University Hospital, Brno, Czechia.
⁴⁷ Faculty of Medicine, Masaryk University, Brno, Czechia.
⁴⁸ Department of Neuroradiology, Hospital Garcia de Orta, Almada, Portugal.
⁴⁹ C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
⁵⁰ Brain Tumour Centre, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
⁵¹ Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.

Abstract

Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation. This review describes current methods, limits, and applications of advanced MRI for the preoperative assessment of glioma, summarizing the level of clinical validation of different techniques. In this second part, we review magnetic resonance spectroscopy (MRS), chemical exchange saturation transfer (CEST), susceptibility-weighted imaging (SWI), MRI-PET, MR elastography (MRE), and MR-based radiomics applications. The first part of this review addresses dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL), diffusion-weighted MRI, vessel imaging, and magnetic resonance fingerprinting (MRF). EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 2.

Keywords: GliMR 2.0; brain; contrasts; glioma; level of clinical validation; preoperative.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Brain Neoplasms* / diagnostic imaging
Brain Neoplasms* / pathology
Brain Neoplasms* / surgery
Contrast Media
Glioma* / diagnostic imaging
Glioma* / pathology
Glioma* / surgery
Humans
Magnetic Resonance Imaging* / methods
Magnetic Resonance Spectroscopy / methods
Preoperative Period

Substances

Contrast Media

Abstract

Publication types

MeSH terms

Substances

Grants and funding