Optimization and analytical behavior of a morphine electrochemical sensor in environmental and biological samples based on graphite rod electrode using graphene/Co3O4 nanocomposite

Chan Wang; Jing Luo; Hao Dou; Amir Raise; Mohammed Sardar Ali; Wei Fan; Qian Li

doi:10.1016/j.chemosphere.2023.138451

Optimization and analytical behavior of a morphine electrochemical sensor in environmental and biological samples based on graphite rod electrode using graphene/Co₃O₄ nanocomposite

Chemosphere. 2023 Jun:326:138451. doi: 10.1016/j.chemosphere.2023.138451. Epub 2023 Mar 20.

Authors

Chan Wang¹, Jing Luo², Hao Dou³, Amir Raise⁴, Mohammed Sardar Ali⁵, Wei Fan¹, Qian Li⁶

Affiliations

¹ School of Textile Science and Engineering, Key Laboratory of Functional Textile Material and Product of Ministry of Education, Xi'an Polytechnic University, Xi'an, 710048, Shaanxi, China.
² Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
³ School of Textile Science and Engineering, Key Laboratory of Functional Textile Material and Product of Ministry of Education, Xi'an Polytechnic University, Xi'an, 710048, Shaanxi, China. Electronic address: [email protected].
⁴ Department of Mechanical Engineering, Faculty of Engineering, Xi'an Technological University, Shaanxi, China. Electronic address: [email protected].
⁵ Department of Information Technology, College of Engineering and Computer Science, Lebanese French University, Kurdistan Region, Iraq.
⁶ People's Hospital of Ningxiang City, Hunan University of Chinese Medicine, Ningxiang, Hunan, 410600, China.

PMID: 36940827
DOI: 10.1016/j.chemosphere.2023.138451

Abstract

In this research, a new sensor based on graphene/Co₃O₄ (Gr/Co₃O₄) nanocomposite was employed for electrochemically determination of morphine (MOR). The modifier was synthesized with a simple hydrothermal technique and well characterized using X-ray difraction (XRD), scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDS) tools. The modified graphite rod electrode (GRE) was revealed a high electrochemical catalytic activity for the MOR oxidation and employed for the electroanalysis of trace MOR concentration by means of differential pulse voltammetry (DPV) technique. At the optimum experimental factors, the resulting sensor offered a good response for MOR in the concentration range of 0.5-100.0 μM with a detection limit of 80 nM. In addition, the modified electrode demonstrated an acceptable selectivity, stability and reproducibility. This assay was also provided a valid platform for the detection of MOR in environmental and biological samples with acceptable recoveries and RSD in the range of 97.2-102.8% and 1.7-3.4%, respectively. Taking to the simplicity, low cost and short analysis time, this approach is suggested for clinical, environmental and forensic testing of MOR.

Keywords: Environmental and biological analysis; Graphene based composite; Modified sensor; Morphine.

MeSH terms

Electrochemical Techniques / methods
Electrodes
Graphite* / chemistry
Morphine Derivatives
Nanocomposites* / chemistry
Reproducibility of Results

Substances

Graphite
cobalt tetraoxide
Morphine Derivatives