Evaluation of the Efficacy of Immune and Inflammatory Markers in the Diagnosis of Lacrimal-Gland Benign Lymphoepithelial Lesion

Fuxiao Luan; Rui Liu; Jing Li; Xin Ge; Nan Wang; Qihan Guo; Yong Tao; Jianmin Ma

doi:10.3390/cimb45030129

Evaluation of the Efficacy of Immune and Inflammatory Markers in the Diagnosis of Lacrimal-Gland Benign Lymphoepithelial Lesion

Curr Issues Mol Biol. 2023 Mar 1;45(3):2013-2020. doi: 10.3390/cimb45030129.

Authors

Fuxiao Luan¹, Rui Liu², Jing Li², Xin Ge², Nan Wang², Qihan Guo², Yong Tao¹, Jianmin Ma²

Affiliations

¹ Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
² Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Abstract

This study retrospectively analyzes the immune and inflammatory indices of patients with lacrimal-gland benign lymphoepithelial lesion (LGBLEL) in order to screen out reference indices with higher diagnostic efficacy. The medical histories of patients whose diagnoses of LGBLEL and primary lacrimal prolapse were confirmed by pathology between August 2010 and August 2019 were collected. In the LGBLEL group, the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, rheumatoid factor (RF), and immunoglobulins G, G1, G2, and G4 (IgG, IgG1, IgG2, IgG4) were higher (p < 0.05) and the expression level of C3 was lower (p < 0.05) compared to the lacrimal-gland prolapse group. Multivariate logistic regression analysis showed that IgG4, IgG, and C3 were independent risk factors for predicting LGBLEL occurrence (p < 0.05). The area under the receiver operating characteristic (ROC) curve of the prediction model (IgG4+IgG+C3) was 0.926, which was significantly better than that of any single factor. Therefore, serum levels of IgG4, IgG, and C3 were independent risk factors for predicting the occurrence of LGBLEL, and the combined diagnostic efficacy of IgG4+IgG+C3 was the highest.

Keywords: benign lymphoepithelial lesions; diagnosis; immune marker; inflammatory marker; lacrimal gland.

Grants and funding

Supported by National Natural Science Foundation of China (82070948), Beijing Hospitals Authority’ Ascent Plan (DFL20190201 and No. DFL20220301), Natural Science Foundation of Beijing (7222025), and Shunyi District Beijing Science and Technology Achievements Transformation Coordination and Service Platform Construction Fund (SYGX202010).