Hyponatremia as a Predictor of Cryptococcal Meningitis and Death Among Asymptomatic Persons With HIV and Cryptococcal Antigenemia

Open Forum Infect Dis. 2023 Mar 28;10(3):ofad156. doi: 10.1093/ofid/ofad156. eCollection 2023 Mar.

Abstract

Among persons with human immunodeficiency virus-associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.

Keywords: HIV; cryptococcal meningitis; hyponatremia.