Association Between Duration of SARS-CoV-2 Positivity and Long COVID

Chiara Pozzi; Riccardo Sarti; Riccardo Levi; Maximiliano Mollura; Elena Azzolini; Riccardo Barbieri; Alberto Mantovani; Maria Rescigno

doi:10.1093/cid/ciad434

Association Between Duration of SARS-CoV-2 Positivity and Long COVID

Clin Infect Dis. 2023 Nov 30;77(11):1531-1533. doi: 10.1093/cid/ciad434.

Authors

Chiara Pozzi¹, Riccardo Sarti^{1

2}, Riccardo Levi^{1

2}, Maximiliano Mollura³, Elena Azzolini^{1

2}, Riccardo Barbieri³, Alberto Mantovani^{1

2

4}, Maria Rescigno^{1

2}

Affiliations

¹ Istituto di Ricovero e Cura a Carattere Scientifico, Humanitas Research Hospital, Rozzano, Milan, Italy.
² Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
³ Politecnico di Milano, Department of Electronic, Information and Bioengineering, Milan, Italy.
⁴ William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

Abstract

In an observational study, we analyzed 1293 healthcare workers previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), of which 34.1% developed postacute sequelae of SARS-CoV-2 infection (also known as long COVID). Using a multivariate logistic regression model, we demonstrate that the likelihood of developing long COVID in infected individuals rises with the increasing of duration of infection and that 3 doses of the BNT162b2 vaccine are protective, even during the Omicron wave.

Keywords: COVID-19; SARS-CoV-2 infection; long COVID; vaccine.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

BNT162 Vaccine
COVID-19*
Disease Progression
Humans
Post-Acute COVID-19 Syndrome*
SARS-CoV-2

Substances

BNT162 Vaccine

Grants and funding

Italian Ministry of Health