Risk factors for developing both primary breast and primary ovarian cancer: A systematic review

Jennifer S Ferris; Devon A Morgan; Ashley S Tseng; Mary Beth Terry; Ruth Ottman; Chin Hur; Jason D Wright; Jeanine M Genkinger

doi:10.1016/j.critrevonc.2023.104081

Risk factors for developing both primary breast and primary ovarian cancer: A systematic review

Crit Rev Oncol Hematol. 2023 Oct:190:104081. doi: 10.1016/j.critrevonc.2023.104081. Epub 2023 Aug 2.

Authors

Jennifer S Ferris¹, Devon A Morgan², Ashley S Tseng², Mary Beth Terry³, Ruth Ottman⁴, Chin Hur⁵, Jason D Wright⁶, Jeanine M Genkinger³

Affiliations

¹ Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA. Electronic address: [email protected].
² Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA.
³ Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, 1130 St Nicholas Ave, New York, NY 10032, USA.
⁴ Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA; G. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Division of Translational Epidemiology and Mental Health Equity, New York State Psychiatric Institute, New York, NY 10032, USA.
⁵ Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, 1130 St Nicholas Ave, New York, NY 10032, USA; Department of Medicine, Columbia University Irving Medical Center, 622 W 168th Street, PH9-105C, New York, NY 10032, USA.
⁶ Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

PMID: 37541535
DOI: 10.1016/j.critrevonc.2023.104081

Abstract

Objective: Women with breast cancer have an increased risk of primary ovarian cancer (BR→OV), and women with ovarian cancer have an increased risk of primary breast cancer (OV→BR). This systematic review summarizes risk factors for developing BR→OV and OV→BR.

Methods: We searched PubMed and Embase until June 2022.

Results: We identified 23 articles meeting our inclusion criteria. Studies observed a lower risk of BR→OV for Black versus White women, alcohol consumption, radiotherapy and hormone therapy, BRCA2 versus BRCA1, and ER/PR positive versus negative breast tumors, and a higher risk with family history of breast/ovarian cancer, triple negative versus luminal breast cancer, and higher grade breast tumors. There was an increased risk of OV→BR with family history of cancer.

Conclusions: Tumor characteristics, and genetic and familial factors are associated with risk of BR→OV and OV→BR. These results could aid clinicians in decision-making for breast and ovarian cancer patients, including risk-reducing strategies.

Keywords: Breast cancer; Ovarian cancer; Risk Factors; Second cancers; Systematic Review.

Publication types

Systematic Review
Review

MeSH terms

Breast Neoplasms* / epidemiology
Breast Neoplasms* / etiology
Breast Neoplasms* / therapy
Female
Genes, BRCA2
Humans
Mutation
Ovarian Neoplasms* / epidemiology
Ovarian Neoplasms* / etiology
Ovarian Neoplasms* / therapy
Risk Factors