Molecular Characterization of Trypanosoma cruzi Reactivation and Follow-up in a Case Series of People With HIV

Marisa Liliana Fernandez; Constanza Lopez Albizu; Diego Nicita; Susana Besuschio; Cinthia Giomi; María Laura Biondi; María Susana Leguizamón; Julian Garcia; Marcelo Corti; Alejandro Schijman; Juan Miguel Burgos

doi:10.1093/ofid/ofad357

Molecular Characterization of Trypanosoma cruzi Reactivation and Follow-up in a Case Series of People With HIV

Open Forum Infect Dis. 2023 Jul 10;10(8):ofad357. doi: 10.1093/ofid/ofad357. eCollection 2023 Aug.

Authors

Affiliations

¹ Instituto Nacional de Parasitología Dr M. Fatala Chabén, Administración Nacional de Laboratorios e Institutos de Salud Dr C. Malbrán, Ministerio de Salud, Buenos Aires, Argentina.
² Departamento de Enfermedades Infecciosas, Hospital de Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.
³ Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr Hector Torres," Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
⁴ IIBIO, Universidad Nacional de San Martín, Buenos Aires, Argentina.
⁵ Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Buenos Aires, Argentina.

Abstract

We characterize Trypanosoma cruzi infections from blood and cerebrospinal fluid samples in a case series of people with human immunodeficiency virus and Chagas disease. We identify different infecting T. cruzi populations, highlighting the usefulness of real-time polymerase chain reaction for Chagas disease reactivation diagnosis and evaluation of treatment response.

Keywords: Chagas disease reactivation; Trypanosoma cruzi; people with HIV; qPCR.