Formulation and Characterization of Mupirocin Nanomicelles in Insulin-Based Gel for Dermatological Application

Maysaa B Zubairi; Abdulkareem H Abd; Mohammed S Al-Lami

doi:10.4103/jpbs.jpbs_172_23

Formulation and Characterization of Mupirocin Nanomicelles in Insulin-Based Gel for Dermatological Application

J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1178-S1181. doi: 10.4103/jpbs.jpbs_172_23. Epub 2023 Jul 11.

Authors

Maysaa B Zubairi¹, Abdulkareem H Abd², Mohammed S Al-Lami³

Affiliations

¹ Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq.
² Department of Pharmacology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
³ Department of Pharmaceutics, College of Pharmacy, University of Basra, Basra, Iraq.

Abstract

Aim: To produce and analyze mupirocin nanomicelle (MP-NM) in insulin-based gel.

Procedures: MP-NM was prepared using solvent evaporation with Tween 80 as a surfactant. HPMC polymer prepared gel. MP-NM was characterized by globular diameter, polydispersity index (PDI), pH, entrapment efficiency (EE), and transmission electron microscopy (TEM). NM MP release was studied in vitro.

Results: The revolutionary MP-NM in insulin-based gel dissolves MP completely without precipitation due to its unique physical and chemical properties. MP had 8.64 ± 0.2 nm globular diameter, high EE (98.85 ± 0.01%), and normal homogeneous dispersion (PDI, 0.143 ± 0.003) in NM. MP's formula showed rapid first-order kinetics release.

Conclusion: To our knowledge, this is the first MP-NM nano-drug delivery system employing insulin-based gel. It has promising pre-clinical and clinical uses.

Keywords: Mupirocin; Tween 80; nano-drug delivery; nanomicelle.