Ependymal cells SCOre sweet cerebrospinal fluid

PLoS Biol. 2023 Sep 22;21(9):e3002323. doi: 10.1371/journal.pbio.3002323. eCollection 2023 Sep.

Abstract

The subcommissural organ (SCO) is a secretory tissue located on the roof of the brain's third ventricle. A new study published in PLOS Biology finds that the SCO responds to glucose by secreting signaling molecules into the cerebrospinal fluid (CSF), thereby decreasing the local ependyma-driven CSF movement.

Publication types

  • Research Support, Non-U.S. Gov't
  • Kommentar

MeSH terms

  • Biological Transport
  • Cell Adhesion Molecules, Neuronal
  • Glucose
  • Humans
  • Hyperglycemia*

Substances

  • SCO-spondin
  • Glucose
  • Cell Adhesion Molecules, Neuronal

Grants and funding

This work was supported by the Shurl and Kay Curci Foundation (R.M.F). https://curcifoundation.org. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.