Advances of nanotechnology for intracerebral hemorrhage therapy

Jiayan Wang; Tianyou Wang; Mei Fang; Zexu Wang; Wei Xu; Bang Teng; Qijuan Yuan; Xin Hu

doi:10.3389/fbioe.2023.1265153

Advances of nanotechnology for intracerebral hemorrhage therapy

Front Bioeng Biotechnol. 2023 Sep 12:11:1265153. doi: 10.3389/fbioe.2023.1265153. eCollection 2023.

Authors

Jiayan Wang^#^{1

2}, Tianyou Wang^#³, Mei Fang^#^{1

2}, Zexu Wang², Wei Xu^{1

2}, Bang Teng^{1

2}, Qijuan Yuan⁴, Xin Hu¹

Affiliations

¹ Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
² West China School of Medicine, Sichuan University, Chengdu, China.
³ State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu, China.
⁴ School of Materials Science and Engineering, Xihua University, Chengdu, China.

^# Contributed equally.

Abstract

Intracerebral hemorrhage (ICH), the most devastating subtype of stoke, is of high mortality at 5 years and even those survivors usually would suffer permanent disabilities. Fortunately, various preclinical active drugs have been approached in ICH, meanwhile, the therapeutic effects of these pharmaceutical ingredients could be fully boosted with the assistance of nanotechnology. In this review, besides the pathology of ICH, some ICH therapeutically available active drugs and their employed nanotechnologies, material functions, and therapeutic principles were comprehensively discussed hoping to provide novel and efficient strategies for ICH therapy in the future.

Keywords: bioavailability; functionality; intracerebral hemorrhage; nanotechnologies; safety; therapeutic agents.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the 1·3·5 Projects for Disciplines of Excellence of West China Hospital of Sichuan University (grant numbers: ZY2016102 and 2021HXFH045), the National Natural Science Foundation of China (grant numbers: 81601155 and 82201453), the Sichuan Science and Technology Program (grant numbers: 2020YFQ0009 and 2023NSFSC1557), and the Project funded by China Postdoctoral Science Foundation (grant number: 2022M722271).