Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits

J Clin Oncol. 2023 Dec 20;41(36):5501-5504. doi: 10.1200/JCO.23.01502. Epub 2023 Oct 17.

Abstract

Positive phase III trials are not truly practice changing if they do not accurately inform on the best options for patients

MeSH terms

  • Antineoplastic Agents* / therapeutic use
  • Humans
  • Male
  • Poly(ADP-ribose) Polymerase Inhibitors / adverse effects
  • Prostatic Neoplasms, Castration-Resistant* / drug therapy
  • Prostatic Neoplasms, Castration-Resistant* / pathology

Substances

  • Poly(ADP-ribose) Polymerase Inhibitors
  • Antineoplastic Agents