Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases: JACC Scientific Statement

Brittany N Weber; Julie J Paik; Ayaz Aghayev; Allan L Klein; Sophie I Mavrogeni; Paul B Yu; Monica Mukherjee

doi:10.1016/j.jacc.2023.09.819

Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases: JACC Scientific Statement

J Am Coll Cardiol. 2023 Nov 28;82(22):2128-2151. doi: 10.1016/j.jacc.2023.09.819.

Authors

Brittany N Weber¹, Julie J Paik², Ayaz Aghayev³, Allan L Klein⁴, Sophie I Mavrogeni⁵, Paul B Yu⁶, Monica Mukherjee⁷

Affiliations

¹ Division of Cardiology, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA.
² Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, USA.
³ Department of Radiology, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA.
⁴ Division of Cardiology, Cleveland Clinic, Cleveland, Ohio, USA.
⁵ Onassis Cardiac Surgery Center, Athens, Greece.
⁶ Division of Cardiology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, USA.
⁷ Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: [email protected].

Abstract

Derangements in the innate and adaptive immune responses observed in systemic inflammatory syndromes contributes to unique elevated atherosclerotic risk and incident cardiovascular disease. Novel multimodality imaging techniques may improve diagnostic precision for the screening and monitoring of disease activity. The integrated application of these technologies lead to earlier diagnosis and noninvasive monitoring of cardiac involvement in systemic inflammatory diseases that will aid in preclinical studies, enhance patient selection, and provide surrogate endpoints in clinical trials, thereby improving clinical outcomes. We review the common cardiovascular manifestations of immune-mediated systemic inflammatory diseases and address the clinical and investigational role of advanced multimodality cardiac imaging.

Keywords: PET; cardiac magnetic resonance; computed tomography; echocardiography; systemic inflammatory disease.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Cardiac Imaging Techniques
Cardiovascular Diseases* / diagnostic imaging
Cardiovascular Diseases* / etiology
Heart*
Humans
Multimodal Imaging / methods

Abstract

Publication types

MeSH terms

Grants and funding