Genome sequence of the Klebsiella quasipneumoniae bacteriophage EKq1 with activity against Klebsiella pneumoniae

Jordan T Bird; Kevin A Burke; Caitlin D Urick; Jamie L Braverman; Nino Mzhavia; Damon W Ellison; Mikeljon P Nikolich; Andrey A Filippov

doi:10.1128/MRA.00954-23

Genome sequence of the Klebsiella quasipneumoniae bacteriophage EKq1 with activity against Klebsiella pneumoniae

Microbiol Resour Announc. 2024 Jan 17;13(1):e0095423. doi: 10.1128/MRA.00954-23. Epub 2023 Nov 30.

Authors

Jordan T Bird¹, Kevin A Burke², Caitlin D Urick², Jamie L Braverman², Nino Mzhavia², Damon W Ellison³, Mikeljon P Nikolich², Andrey A Filippov²

Affiliations

¹ Department of Biochemistry and Molecular Biology, University of Arkansas , Little Rock, Arkansas, USA.
² Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research , Silver Spring, Maryland, USA.
³ Bacterial Diseases Branch, Walter Reed Army Institute of Research , Silver Spring, Maryland, USA.

Abstract

We describe the genome of a lytic phage EKq1 isolated on Klebsiella quasipneumoniae, with activity against Klebsiella pneumoniae. EKq1 is an unclassified representative of the class Caudoviricetes, similar to Klebsiella phages VLCpiS8c, phiKp_7-2, and vB_KleS-HSE3. The 48,244-bp genome has a GC content of 56.43% and 63 predicted protein-coding genes.

Keywords: Klebsiella pneumoniae; Klebsiella quasipneumoniae; class Caudoviricetes; complete genome sequence; lytic phage; phage EKq1; therapeutic candidate; unclassified Caudoviricetes.

Grants and funding

MI210045/Military Infectious Diseases Research Program