Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis

Mehrdad Valizadeh; Ehsan Derafsh; Fahimeh Abdi Abyaneh; Sayedeh Kiana Parsamatin; Fatemeh Zahra Rashidi Noshabad; Azam Alinaghipour; Zahra Yaghoobi; Abdolkarim Talebi Taheri; Ehsan Dadgostar; Michael Aschner; Hamed Mirzaei; Omid Reza Tamtaji; Fatemeh Nabavizadeh

doi:10.1007/s12035-023-03849-z

Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis

Mol Neurobiol. 2024 Jul;61(7):4508-4537. doi: 10.1007/s12035-023-03849-z. Epub 2023 Dec 16.

Authors

Mehrdad Valizadeh¹, Ehsan Derafsh², Fahimeh Abdi Abyaneh³, Sayedeh Kiana Parsamatin⁴, Fatemeh Zahra Rashidi Noshabad⁵, Azam Alinaghipour⁶, Zahra Yaghoobi^{7

8}, Abdolkarim Talebi Taheri⁹, Ehsan Dadgostar^{10

11}, Michael Aschner¹², Hamed Mirzaei¹³, Omid Reza Tamtaji^{14

15}, Fatemeh Nabavizadeh^{7

8}

Affiliations

¹ Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Windsor University School of Medicine, Cayon, Canada.
³ School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
⁴ Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Student Research Committee, Kashan University of Medical Sciences, Kashan, IR, Iran.
⁶ School of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran.
⁷ Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IR, Iran.
⁸ Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, IR, Iran.
⁹ Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹⁰ Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, IR, Iran.
¹¹ Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IR, Iran.
¹² Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
¹³ Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran. [email protected].
¹⁴ Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IR, Iran. [email protected].
¹⁵ Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, IR, Iran. [email protected].

PMID: 38102518
DOI: 10.1007/s12035-023-03849-z

Abstract

Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and tissue damage may become apparent. Recently, the scientific studies of the non-coding RNAs (ncRNAs) has provided new information of the molecular mechanisms that contribute to neurodegenerative disorders. Numerous reports have documented that ncRNAs have important contributions to several biological processes associated with the increase of neurodegenerative disorders. In addition, microRNAs (miRNAs), circular RNAs (circRNAs), as well as, long ncRNAs (lncRNAs) represent ncRNAs subtypes with the usual dysregulation in neurodegenerative disorders. Dysregulating ncRNAs has been associated with inhibiting or stimulating apoptosis in neurodegenerative disorders. Therefore, this review highlighted several ncRNAs linked to apoptosis in neurodegenerative disorders. CircRNAs, lncRNAs, and miRNAs were also illustrated completely regarding the respective signaling pathways of apoptosis.

Keywords: Apoptosis; Circular RNA; Long non-coding RNA; MicroRNA; Neurodegenerative disorders.

Publication types

Review

MeSH terms

Animals
Apoptosis* / genetics
Humans
MicroRNAs / genetics
MicroRNAs / metabolism
Neurodegenerative Diseases* / genetics
Neurodegenerative Diseases* / metabolism
Neurodegenerative Diseases* / pathology
RNA, Circular / genetics
RNA, Circular / metabolism
RNA, Untranslated* / genetics
RNA, Untranslated* / metabolism
Signal Transduction / genetics

Substances

RNA, Untranslated
RNA, Circular
MicroRNAs