Cerebellar metastasis of ovarian cancer: a case report

J Med Case Rep. 2023 Dec 19;17(1):553. doi: 10.1186/s13256-023-04211-6.

Abstract

Background: Ovarian cancer is metastatic at presentation in about 62% of cases, but brain metastases are rare, reported in 3.3-4% of patients. Brain metastasis seems to be more frequent in advanced stages at diagnosis and in patients with BRCA1/2 mutation.

Case presentation: We present a case of a 47-year-old Caucasian woman, BRCA wild type, with an ovarian cancer that started with single cerebellar metastasis.

Conclusion: Brain metastases in ovarian cancer are rare and complex for diagnosis and management. This case focuses both on diagnosis and treatment, emphasizing the importance of a multimodal approach in a multidisciplinary team.

Keywords: Brain metastasis; Case report; Multimodal approach; Ovarian cancer; PARP inhibitor.

Publication types

  • Case Reports

MeSH terms

  • BRCA1 Protein / genetics
  • BRCA2 Protein / genetics
  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / therapy
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms* / pathology

Substances

  • BRCA1 protein, human
  • BRCA1 Protein
  • BRCA2 protein, human
  • BRCA2 Protein