Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Affiliations

• ¹ Division of Psychiatry, UCL, London, UK.
• ² UCL Genetics Institute, UCL, London, UK.
• ³ Department of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.
• ⁴ Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
• ⁵ Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain.
• ⁶ SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
• ⁷ Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• ⁸ Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
• ⁹ Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ¹⁰ Department of Medicine, VA Boston Healthcare System, Boston, MA, USA.
• ¹¹ Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• ¹² Department of Medicine, Harvard Medical School, Boston, MA, USA.
• ¹³ SAMRC Unit on Child and Adolescent Health, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
• ¹⁴ Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
• ¹⁵ Blizard Institute, Queen Mary University of London, London, UK.
• ¹⁶ Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
• ¹⁷ Wellcome Sanger Institute, Saffron Walden, UK.
• ¹⁸ Department of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
• ¹⁹ Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.
• ²⁰ Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
• ²¹ Institute of Brain Science and Division of Psychiatry, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
• ²² Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
• ²³ Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan.
• ²⁴ Department of Psychiatry, VCU, Richmond, VA, USA.
• ²⁵ Department of Psychiatry, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
• ²⁶ Helmholtz Pioneer Campus, Helmholtz Munich, Neuherberg, Germany.
• ²⁷ Computational Health Centre, Helmholtz Munich, Neuherberg, Germany.
• ²⁸ Department of Medicine, Technical University of Munich, Munich, Germany.
• ²⁹ Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
• ³⁰ Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
• ³¹ Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
• ³² Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
• ³³ Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
• ³⁴ Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
• ³⁵ Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ³⁶ Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• ³⁷ Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
• ³⁸ Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
• ³⁹ Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
• ⁴⁰ College of Public Health, University of South Florida, Tampa, FL, USA.
• ⁴¹ Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.
• ⁴² Robert N. Butler Columbia Aging Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
• ⁴³ Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
• ⁴⁴ Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
• ⁴⁵ Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
• ⁴⁶ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
• ⁴⁷ Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
• ⁴⁸ Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
• ⁴⁹ Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• ⁵⁰ Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• ⁵¹ Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
• ⁵² Neurology and Pharmacology, University of Maryland, Maryland VA Healthcare System, Baltimore, MD, USA.
• ⁵³ Departamento de Genética, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñíz', Mexico City, Mexico.
• ⁵⁴ Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
• ⁵⁵ MRC Population Health Research Unit, University of Oxford, Oxford, UK.
• ⁵⁶ Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
• ⁵⁷ Peking University Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China.
• ⁵⁸ Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
• ⁵⁹ Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
• ⁶⁰ Department of Biostatistics, Emory University, Atlanta, GA, USA.
• ⁶¹ 23andMe, Inc., Mountain View, CA, USA.
• ⁶² Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ⁶³ Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
• ⁶⁴ Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
• ⁶⁵ Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
• ⁶⁶ Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
• ⁶⁷ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Cambridge, MA, USA.
• ⁶⁸ Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• ⁶⁹ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• ⁷⁰ Institute for Genomics and Cancer, University of Edinburgh, Edinburgh, UK.
• ⁷¹ VA Connecticut Healthcare Center, West Haven, CT, USA.
• ⁷² Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
• ⁷³ Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA.
• ⁷⁴ Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
• ⁷⁵ Department of Psychiatry, UC San Diego School of Medicine, La Jolla, CA, USA.
• ⁷⁶ Herbert Wertheim School of Public Health and Human Longevity, University of California San Diego, La Jolla, CA, USA.
• ⁷⁷ Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA.
• ⁷⁸ Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
• ⁷⁹ Department of Medical and Molecular Genetics, King's College London, London, UK.
• ⁸⁰ Division of Psychiatry, UCL, London, UK. [email protected].
• ⁸¹ UCL Genetics Institute, UCL, London, UK. [email protected].