Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer

Affiliations

• ¹ UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
• ² Earle A Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
• ³ Department of Pathology PA2, GZA-ZNA Hospitals, Antwerp, Belgium.
• ⁴ Centre for Oncological Research (CORE), MIPPRO, Faculty of Medicine, Antwerp University, Antwerp, Belgium.
• ⁵ Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• ⁶ Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
• ⁷ Departments of Pathology and Dermatology, University of Michigan, Ann Arbor, MI, USA.
• ⁸ Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY, USA.
• ⁹ Institute of Pathology, Klinikum Bayreuth GmbH, Friedrich-Alexander-University Erlangen-Nuremberg, Bayreuth, Germany.
• ¹⁰ Department of Pathology, Matsuyama Shimin Hospital, Matsuyama, Japan.
• ¹¹ Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
• ¹² Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer, Vancouver, British Columbia, Canada.
• ¹³ Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
• ¹⁴ Johns Hopkins Oncology Center, Baltimore, MD, USA.
• ¹⁵ Digestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
• ¹⁶ Technical University of Denmark, Kgs. Lyngby, Denmark.
• ¹⁷ Visiopharm A/S, Hørsholm, Denmark.
• ¹⁸ Department of Cellular Pathology, University College Hospital, London, UK.
• ¹⁹ Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
• ²⁰ Hospital Maria Curie, Buenos Aires, Argentina.
• ²¹ Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
• ²² Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.
• ²³ Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
• ²⁴ Department of Medicine, NYU Grossman School of Medicine, Manhattan, NY, USA.
• ²⁵ Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA.
• ²⁶ Oncology Hospital, Star Medica Centro, Juarez City, Mexico.
• ²⁷ Tehran University of Medical Sciences, Tehran, Iran.
• ²⁸ Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Emory University Winship Cancer Institute, Atlanta, GA, USA.
• ²⁹ The National University of Malaysia, Kuala Lumpur, Malaysia.
• ³⁰ Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.
• ³¹ Department of Pathology, Narayana Medical College, Nellore, India.
• ³² Department of Internal Medicine Section of Medical Oncology and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
• ³³ Department of Computer Science, Yale School of Engineering and Applied Science, New Haven, CT, USA.
• ³⁴ Amazonas Federal University, Manaus, Brazil.
• ³⁵ Pathology Department, Hospital Cliníco Universitario de Valencia/Incliva, Valencia, Spain.
• ³⁶ Department of Pathobiology & Population Sciences, The Royal Veterinary College, London, UK.
• ³⁷ Head of Integrative Genomics Analysis in Clinical Trials, ICR-CTSU, Division of Clinical Studies, The Institute of Cancer Research, London, UK.
• ³⁸ Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
• ³⁹ Department of Pathology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
• ⁴⁰ Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, KU Leuven, Leuven, Belgium.
• ⁴¹ Biomedical Engineering Department, Emory University, Atlanta, GA, USA.
• ⁴² Hospital Universitário Getúlio Vargas, Manaus, Brazil.
• ⁴³ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
• ⁴⁴ Department of Pathology, Weill Cornell Medicine, New York, NY, USA.
• ⁴⁵ Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
• ⁴⁶ University of Surrey, Guildford, UK.
• ⁴⁷ Ain Shams University, Cairo, Egypt.
• ⁴⁸ Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano, HUMAN-tech, Universitat Politècnica de València, Valencia, Spain.
• ⁴⁹ Montefiore Medical Center and the Albert Einstein College of Medicine, New York, NY, USA.
• ⁵⁰ Pathology, Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
• ⁵¹ Genentech, San Francisco, CA, USA.
• ⁵² Department of Oncological Sciences, Medicine Hem/Onc, and Pathology, Tisch Cancer Institute - Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ⁵³ Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
• ⁵⁴ Cancer Bioinformatics, Faculty of Life Sciences and Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK.
• ⁵⁵ The Breast Cancer Now Research Unit, Faculty of Life Sciences and Medicine, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
• ⁵⁶ Department of Translational Immunotherapy, German Cancer Research Center, Heidelberg, Germany.
• ⁵⁷ Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• ⁵⁸ Case Western University, Cleveland, OH, USA.
• ⁵⁹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
• ⁶⁰ Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
• ⁶¹ Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
• ⁶² Division of Pathology, Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.
• ⁶³ Praava Health, Dhaka, Bangladesh.
• ⁶⁴ King's College London & Guys & St Thomas NHS Trust, London, UK.
• ⁶⁵ Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
• ⁶⁶ Department of Chemistry, Bioscience and Environmental Technology, University of Stavanger, Stavanger, Norway.
• ⁶⁷ Department of Pathology, Iwate Medical University, Morioka, Japan.
• ⁶⁸ Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
• ⁶⁹ Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
• ⁷⁰ Histopathology, Aakash Healthcare Super Speciality Hospital, New Delhi, India.
• ⁷¹ Department of Pathology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
• ⁷² Data, Analytics and Imaging, Product Development, F. Hoffmann-La Roche AG, Basel, Switzerland.
• ⁷³ Translational Molecular Biomarkers, Merck & Co., Inc., Kenilworth, NJ, USA.
• ⁷⁴ Translational Medicine, Bristol Myers Squibb, Princeton, NJ, USA.
• ⁷⁵ Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
• ⁷⁶ Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
• ⁷⁷ Department of Surgical Pathology, Zealand University Hospital, Roskilde, Denmark.
• ⁷⁸ Department of Surgical Pathology, University of Copenhagen, Copenhagen, Denmark.
• ⁷⁹ Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
• ⁸⁰ Center for Integrated Diagnostics, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
• ⁸¹ Centre for Computational Biology (CBIO), Mines Paris, PSL University, Paris, France.
• ⁸² Institut Curie, PSL University, Paris, France.
• ⁸³ INSERM U900, Paris, France.
• ⁸⁴ Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
• ⁸⁵ Department of Biomedical Engineering, Radiology and Imaging Sciences, Biomedical Informatics, Pathology, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
• ⁸⁶ NRG Oncology/NSABP Foundation, Pittsburgh, PA, USA.
• ⁸⁷ Manipal Hospitals, Bangalore, India.
• ⁸⁸ Breast Cancer Translational Research Group, University of Pennsylvania, Philadelphia, PA, USA.
• ⁸⁹ Indian Cancer Genomic Atlas, Pune, India.
• ⁹⁰ Centre for Health, Innovation and Policy Foundation, Noida, India.
• ⁹¹ Office of Biostatistics and Epidemiology, Gustave Roussy, Oncostat U1018, Inserm, University Paris-Saclay, Ligue Contre le Cancer labeled Team, Villejuif, France.
• ⁹² Department of Pathology, Narayana Medical College and Hospital, Nellore, India.
• ⁹³ Tissue Image Analytics Centre, Warwick Cancer Research Centre, PathLAKE Consortium, Department of Computer Science, University of Warwick, Coventry, UK.
• ⁹⁴ Department of Chemical Engineering, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
• ⁹⁵ CRUK Lung Cancer Centre of Excellence, UCL and Cellular Pathology Department, UCLH, London, UK.
• ⁹⁶ Department of Biochemistry, Ziauddin University, Karachi, Pakistan.
• ⁹⁷ Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Raipur, India.
• ⁹⁸ Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
• ⁹⁹ Department of Clinical Pathology, Drammen Sykehus, Vestre Viken HF, Drammen, Norway.
• ¹⁰⁰ Service de Pathologie et Biopathologie, Centre Jean PERRIN, INSERM U1240 Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne, Clermont-Ferrand, France.
• ¹⁰¹ School of Electrical, Mechanical and Infrastructure Engineering, University of Melbourne, Melbourne, Victoria, Australia.
• ¹⁰² Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
• ¹⁰³ Radiogenomics Laboratory, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
• ¹⁰⁴ Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
• ¹⁰⁵ Department of Oncology, Lakeshore Animal Health Partners, Mississauga, Ontario, Canada.
• ¹⁰⁶ Centre for Advancing Responsible and Ethical Artificial Intelligence (CARE-AI), University of Guelph, Guelph, Ontario, Canada.
• ¹⁰⁷ Diagnostico de Salud Animal SA, Ciudad de México, Mexico.
• ¹⁰⁸ Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
• ¹⁰⁹ Faculty of Medicine and Surgery, University of Milan, Milan, Italy.
• ¹¹⁰ Yale Cancer Center, Yale University, New Haven, CT, USA.
• ¹¹¹ Department of Medical Oncology, Yale School of Medicine, Yale University, New Haven, CT, USA.
• ¹¹² University of Warwick, Coventry, UK.
• ¹¹³ The Medical Oncology Centre of Rosebank, Johannesburg, South Africa.
• ¹¹⁴ Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
• ¹¹⁵ Institute of Pathology, University Hospital Düsseldorf and Heinrich-Heine-University, Düsseldorf, Germany.
• ¹¹⁶ Breast Unit, Institute Gustave Roussy, Villejuif, France.
• ¹¹⁷ Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
• ¹¹⁸ Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
• ¹¹⁹ Department of Diagnostic and Theranostic Medicine, Institut Curie, University Paris-Sciences et Lettres, Paris, France.
• ¹²⁰ Department of Biomedical Informatics, Stony Brook Medicine, New York, NY, USA.
• ¹²¹ Department of Pathology, Aga Khan University, Nairobi, Kenya.
• ¹²² iRhythm Technologies Inc., San Francisco, CA, USA.
• ¹²³ Mater Misericordiae University Hospital, Dublin, Ireland.
• ¹²⁴ Department of Pathology, Section of Breast Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• ¹²⁵ Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (H.U.B), Université Libre de Bruxelles (ULB), Brussels, Belgium.
• ¹²⁶ Medical Oncology Department, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (H.U.B), Université Libre de Bruxelles (ULB), Brussels, Belgium.
• ¹²⁷ Institute of Pathology, University Hospital Heidelberg, Centers for Personalized Medicine (ZPM), Heidelberg, Germany.
• ¹²⁸ King Hussein Cancer Center, Amman, Jordan.
• ¹²⁹ Department of Medical Oncology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
• ¹³⁰ University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ¹³¹ Kyoto University, Kyoto, Japan.
• ¹³² Tempus Labs, Chicago, IL, USA.
• ¹³³ AI for Oncology Lab, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
• ¹³⁴ Mayo Clinic, Jacksonville, FL, USA.
• ¹³⁵ Department of Pathology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
• ¹³⁶ Department of Radiation Oncology, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Canada.
• ¹³⁷ Department of Pathology, European Institute of Oncology & University of Milan, Milan, Italy.
• ¹³⁸ Tissue Image Analytics Centre, Department of Computer Science, University of Warwick, Coventry, UK.
• ¹³⁹ CellCarta NV, Antwerp, Belgium.
• ¹⁴⁰ Fudan Medical University Shanghai Cancer Center, Shanghai, PR China.
• ¹⁴¹ Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ¹⁴² University of Edinburgh, Edinburgh, UK.
• ¹⁴³ Department of Medicine and Research, German Breast Group, Neu-Isenburg, Germany.
• ¹⁴⁴ Institut für Pathologie, Philipps-Universität Marburg und Universitätsklinikum Marburg, Marburg, Germany.
• ¹⁴⁵ The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia.
• ¹⁴⁶ Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.
• ¹⁴⁷ Department of Pathology, Herlev and Gentofte Hospital, Herlev, Denmark.
• ¹⁴⁸ UCD School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.