Regulation of myocardial glucose metabolism by YAP/TAZ signaling

J Cardiol. 2024 May;83(5):323-329. doi: 10.1016/j.jjcc.2024.01.002. Epub 2024 Jan 23.

Abstract

The heart utilizes glucose and its metabolites as both energy sources and building blocks for cardiac growth and survival under both physiological and pathophysiological conditions. YAP/TAZ, transcriptional co-activators of the Hippo pathway, are key regulators of cell proliferation, survival, and metabolism in many cell types. Increasing lines of evidence suggest that the Hippo-YAP/TAZ signaling pathway is involved in the regulation of both physiological and pathophysiological processes in the heart. In particular, YAP/TAZ play a critical role in mediating aerobic glycolysis, the Warburg effect, in cardiomyocytes. Here, we summarize what is currently known about YAP/TAZ signaling in the heart by focusing on the regulation of glucose metabolism and its functional significance.

Keywords: Glucose metabolism; Glycolysis; Heart; Hippo signaling; YAP/TAZ.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptor Proteins, Signal Transducing* / metabolism
  • Glucose
  • Humans
  • Phosphoproteins / metabolism
  • Signal Transduction
  • Trans-Activators* / metabolism
  • Transcription Factors / metabolism
  • Transcriptional Coactivator with PDZ-Binding Motif Proteins
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Trans-Activators
  • YAP-Signaling Proteins
  • Glucose
  • Transcriptional Coactivator with PDZ-Binding Motif Proteins
  • Transcription Factors
  • Phosphoproteins