Accessing Medium-Sized Rings via Vinyl Carbocation Intermediates

Org Lett. 2024 Feb 9;26(5):1000-1005. doi: 10.1021/acs.orglett.3c04014. Epub 2024 Jan 31.

Abstract

Medium-sized rings (8-11-membered cycles) are often more challenging to synthesize than smaller rings (5-7-membered cycles) due to ring strain. Herein, we report a catalytic method for forming 8- and 9-membered rings that proceeds via the intramolecular Friedel-Crafts reactions of vinyl carbocation intermediates. These reactive species are generated catalytically through the ionization of vinyl toluenesulfonates by a Lewis acidic lithium cation-weakly coordinating anion salt.