CRISPR/Cas9-mediated knock-in cells of the late-onset Alzheimer's disease-risk variant, SHARPIN G186R, reveal reduced NF-κB pathway and accelerated Aβ secretion

MeSH terms

• Alzheimer Disease* / genetics
• Alzheimer Disease* / metabolism
• Alzheimer Disease* / pathology
• Amyloid beta-Peptides* / genetics
• Amyloid beta-Peptides* / metabolism
• CRISPR-Cas Systems*
• Gene Knock-In Techniques
• Humans
• NF-kappa B* / genetics
• NF-kappa B* / metabolism
• Signal Transduction / genetics