Clinical profile of Spanish hepatitisC virus-infected treatment-naïve patients with compensated cirrhosis in the CREST study

Gastroenterol Hepatol. 2024 Jun-Jul;47(6):605-611. doi: 10.1016/j.gastrohep.2024.02.003. Epub 2024 Feb 13.
[Article in English, Spanish]

Abstract

Background and aim of the study: There are still patients with hepatitisC in Spain who have yet to be diagnosed, but their clinical profile is unclear. In 2021, 21.93% of patients diagnosed had cirrhosis and were mostly treatment-naïve.

Methods: This sub-analysis describes the clinical profile of the 60Spanish treatment-naïve patients with compensated cirrhosis who were included in the CREST study.

Major results: Sixty percent of patients were male, median age 56years, and 33% had a history of drug use. Almost three-quarters (71.3%) had more than one comorbidity and 78.3% took concomitant medication. At treatment initiation, median platelet count was 139×103/μL and FibroScan® 17kPa. No virological failure was observed and no patient discontinued treatment due to adverse events. No clinically significant changes were noted during or after treatment in the median platelet, albumin, bilirubin, and transaminase levels.

Conclusions: Treatment with glecaprevir/pibrentasvir for 8weeks in this cohort of treatment-naïve patients with compensated cirrhosis in Spain was safe and effective. This information reinforces the use of this short antiviral regimen even when there is compensated cirrhosis, simplifying the approach to hepatitisC among those patients still to be diagnosed and treated in Spain.

Keywords: Cirrosis hepática; Duración de la terapia; Duration of therapy; España; Glecaprevir and pibrentasvir; Glecaprevir y pibrentasvir; Hepatitis C; Liver cirrhosis; Spain.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Antiviral Agents* / therapeutic use
  • Benzimidazoles / therapeutic use
  • Female
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / drug therapy
  • Humans
  • Leucine / analogs & derivatives
  • Leucine / therapeutic use
  • Liver Cirrhosis*
  • Male
  • Middle Aged
  • Pyrrolidines / therapeutic use
  • Spain / epidemiology
  • Sulfonamides / therapeutic use