Inflammatory/juvenile-like polyps in neurofibromatosis type 1 associated with epithelial dysplasia

Virchows Arch. 2024 May;484(5):865-868. doi: 10.1007/s00428-024-03769-w. Epub 2024 Feb 24.

Abstract

The term "juvenile-like (inflammatory/hyperplastic) mucosal polyps" (JLIHMP) has been recently introduced to describe a spectrum of polypoid lesions in patients with neurofibromatosis type 1 (NF-1). Due to the scarce number of reported cases and histopathological similarities with entities such as sporadic/syndromic juvenile polyps or inflammatory fibroid polyps, this entity remains a subject of debate. We describe herein a case of multiple JLIHMPs in a patient with NF-1, and we document the presence of low-grade dysplasia within one of these polyps.

Keywords: Colonic polyps; Epithelial dysplasia; Juvenile-like polyps; Neurofibromatosis type I.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Humans
  • Hyperplasia / pathology
  • Inflammation / pathology
  • Neurofibromatosis 1* / complications
  • Neurofibromatosis 1* / diagnosis
  • Neurofibromatosis 1* / pathology
  • Polyps* / pathology