Probing heterogeneity to identify individualized treatment approaches in autism: Specific clusters of executive function challenges link to distinct co-occurring mental health problems

Autism. 2024 Nov;28(11):2834-2847. doi: 10.1177/13623613241246091. Epub 2024 Apr 20.

Abstract

Many autistic people struggle with mental health problems like anxiety, depression, inattention, and aggression, which can be challenging to treat. Executive function challenges, which impact many autistic individuals, may serve as a risk factor for mental health problems or make treating mental health conditions more difficult. While some people respond well to medication or therapy, others do not. This study tried to understand if there are different subgroups of autistic young people who may have similar patterns of executive function strengths and challenges-like flexibility, planning, self-monitoring, and emotion regulation. Then, we investigated whether executive function subgroups were related to mental health problems in autistic youth. We found three different types of executive function subgroups in autistic youth, each with different patterns of mental health problems. This helps us identify specific profiles of executive function strengths and challenges that may be helpful with identifying personalized supports, services, and treatment strategies for mental health conditions.

Keywords: anxiety; autism spectrum disorders; depression; executive function; psychiatric comorbidity.

MeSH terms

  • Adolescent
  • Autism Spectrum Disorder / psychology
  • Autistic Disorder / complications
  • Autistic Disorder / psychology
  • Child
  • Emotional Regulation
  • Executive Function*
  • Female
  • Humans
  • Male
  • Mental Disorders*
  • Precision Medicine / methods
  • Young Adult