Abstract
Human blood B lymphocytes were cocultured with autologous T lymphocytes which were pretested with melphalan or adriamycin in the presence of pokeweed mitogen (PWM). Melphalan treatment of the cells produced an increased secretion of IgG and IgM, whereas adriamycin did not.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
B-Lymphocytes / drug effects
-
B-Lymphocytes / immunology*
-
Doxorubicin / pharmacology
-
Humans
-
Immunoglobulin G / biosynthesis*
-
Immunoglobulin M / biosynthesis*
-
Melphalan / pharmacology*
-
Pokeweed Mitogens / pharmacology
-
T-Lymphocytes / drug effects*
-
T-Lymphocytes / immunology
Substances
-
Immunoglobulin G
-
Immunoglobulin M
-
Pokeweed Mitogens
-
Doxorubicin
-
Melphalan