Ribosomal DNA and Neurological Disorders

Hong Zhou; Yuqing Xia; Rui Zhu; Yuemei Zhang; Xinming Zhang; Yongjian Zhang; Jun Wang

doi:10.2174/0115665240292079240513093708

Ribosomal DNA and Neurological Disorders

Curr Mol Med. 2024 May 21. doi: 10.2174/0115665240292079240513093708. Online ahead of print.

Authors

Hong Zhou^{1

2

3

4}, Yuqing Xia^{1

2

3

4}, Rui Zhu^{1

2

3

4}, Yuemei Zhang^{1

2

3

4}, Xinming Zhang^{1

2

3

4}, Yongjian Zhang^{1

2

3

4}, Jun Wang^{1

2

3

4}

Affiliations

¹ Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei University of Technology, Wuhan 430030, Hubei, China.
² International Center for Redox Biology & Precision Medicine of Hubei Province, Hubei University of Technology, Wuhan 430030, Hubei, China.
³ National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430030, Hubei, China.
⁴ Department of Biomedicine and Biopharmacology, Hubei University of Technology, Wuhan 430030, Hubei, China.

PMID: 38778614
DOI: 10.2174/0115665240292079240513093708

Abstract

Ribosomal DNA (rDNA) is important in the nucleolus and nuclear organization of human cells. Defective rDNA repeat maintenance has been reported to be closely associated with neurological disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, depression, suicide, etc. However, there has not been a comprehensive review on the role of rDNA in these disorders. In this review, we have summarized the role of rDNA in major neurological disorders to sort out the correlation between rDNA and neurological diseases and provided insights for therapy with rDNA as a target.

Keywords: ALS-FTD; Alzheimer’s disease; Huntington’s disease; Parkinson's disease; Ribosomal DNA; depression; neurological disorders; suicide..