Abstract
A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO- in living cells, image ONOO- in paw edema mice and evaluate anti-inflammatory drugs.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use
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Edema* / chemically induced
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Edema* / diagnostic imaging
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Edema* / drug therapy
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Fluorescent Dyes* / chemical synthesis
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Fluorescent Dyes* / chemistry
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Humans
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Infrared Rays
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Mice
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Optical Imaging
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Peroxynitrous Acid* / analysis
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Peroxynitrous Acid* / metabolism
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RAW 264.7 Cells
Substances
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Peroxynitrous Acid
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Fluorescent Dyes
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Anti-Inflammatory Agents