Reconstructed colorectal cancer model to dissect the anti-tumor effect of mesenchymal stromal cells derived extracellular vesicles

Edoardo D'Angelo; Sarah Tassinari; Andrea Biccari; Sara Crotti; Francesca Sensi; Asia Marangio; Ombretta Repetto; Giuseppe Corona; Linda Bellucci; Federica Antico; Federico Caicci; Gaya Spolverato; Giovanni Montini; Benedetta Bussolati; Marco Agostini; Federica Collino

doi:10.1186/s40164-024-00526-2

Reconstructed colorectal cancer model to dissect the anti-tumor effect of mesenchymal stromal cells derived extracellular vesicles

Exp Hematol Oncol. 2024 Jun 18;13(1):61. doi: 10.1186/s40164-024-00526-2.

Authors

Edoardo D'Angelo^{1

2}, Sarah Tassinari³, Andrea Biccari⁴, Sara Crotti⁵, Francesca Sensi^{5

6}, Asia Marangio⁴, Ombretta Repetto⁷, Giuseppe Corona⁷, Linda Bellucci^{8

9}, Federica Antico³, Federico Caicci¹⁰, Gaya Spolverato⁴, Giovanni Montini^{8

9

11}, Benedetta Bussolati³, Marco Agostini^#^{4

5}, Federica Collino^#^{12

13

14}

Affiliations

¹ General Surgery 3, Department of Surgery, Oncology and Gastroenterology, University of Padova, via Giustiniani 2, Padua, 35128, Italy. [email protected].
² NanoInspired biomedicine lab, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padua, Italy. [email protected].
³ Department of Medical Sciences, University of Turin, Turin, 10126, Italy.
⁴ General Surgery 3, Department of Surgery, Oncology and Gastroenterology, University of Padova, via Giustiniani 2, Padua, 35128, Italy.
⁵ NanoInspired biomedicine lab, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padua, Italy.
⁶ Department of Women and Children's Health, University of Padova, via Giustiniani 2, Padua, 35128, Italy.
⁷ Immunopathology and Cancer Biomarkers, CRO Aviano, National Cancer Institute, IRCCS, Aviano, 33081, Italy.
⁸ Laboratory of Translational Research in Paediatric Nephro-urology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Italy.
⁹ Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Italy.
¹⁰ Department of Biology, University of Padova, Padua, 35131, Italy.
¹¹ Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
¹² Laboratory of Translational Research in Paediatric Nephro-urology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Italy. [email protected].
¹³ Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Italy. [email protected].
¹⁴ Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy. [email protected].

^# Contributed equally.

No abstract available

Keywords: 3D model; Colorectal cancer; Extracellular vesicles; Mesenchymal stromal cells.

Publication types

Letter

Publication types

Grants and funding