Molecular subtypes of ischemic heart disease based on circadian rhythm

Zhaokai Zhou; Ge Zhang; Zhan Wang; Yudi Xu; Hongzhuo Qin; Haonan Zhang; Pengpeng Zhang; Zhengrui Li; Shuai Xu; Xin Tan; Yiyao Zeng; Fengyi Yu; Shanshan Zhu; Le Chang; Youyang Zheng; Xinwei Han

doi:10.1038/s41598-024-65236-5

Molecular subtypes of ischemic heart disease based on circadian rhythm

Sci Rep. 2024 Jun 19;14(1):14155. doi: 10.1038/s41598-024-65236-5.

Authors

Zhaokai Zhou^#^{1

2}, Ge Zhang^#³, Zhan Wang^#², Yudi Xu^#⁴, Hongzhuo Qin⁴, Haonan Zhang⁵, Pengpeng Zhang⁶, Zhengrui Li⁷, Shuai Xu^{8

9}, Xin Tan^{8

9}, Yiyao Zeng^{8

9}, Fengyi Yu³, Shanshan Zhu¹⁰, Le Chang¹¹, Youyang Zheng¹², Xinwei Han^{13

14

15}

Affiliations

¹ Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
² Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
³ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
⁴ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
⁵ Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁶ Department of Lung Cancer, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
⁷ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁸ Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, China.
⁹ Institute for Hypertension, Soochow University, Suzhou, 215000, China.
¹⁰ Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, China.
¹¹ School of Medicine, Zhengzhou University, Zhengzhou, China.
¹² Department of Cardiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, National Clinical Research Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹³ Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. [email protected].
¹⁴ Interventional Institute of Zhengzhou University, Zhengzhou, 450052, Henan, China. [email protected].
¹⁵ Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, 450052, Henan, China. [email protected].

^# Contributed equally.

Abstract

Coronary atherosclerotic heart disease (CAD) is among the most prevalent chronic diseases globally. Circadian rhythm disruption (CRD) is closely associated with the progression of various diseases. However, the precise role of CRD in the development of CAD remains to be elucidated. The Circadian rhythm disruption score (CRDscore) was employed to quantitatively assess the level of CRD in CAD samples. Our investigation revealed a significant association between high CRDscore and adverse prognosis in CAD patients, along with a substantial correlation with CAD progression. Remarkably distinct CRDscore distributions were also identified among various subtypes. In summary, we have pioneered the revelation of the relationship between CRD and CAD at the single-cell level and established reliable markers for the development, treatment, and prognosis of CAD. A deeper understanding of these mechanisms may offer new possibilities for incorporating "the therapy of coronary heart disease based circadian rhythm" into personalized medical treatment regimens.

Keywords: Bioinformatics; Circadian rhythm; Ischemic heart disease; Transcriptome.

MeSH terms

Aged
Biomarkers
Circadian Rhythm* / physiology
Coronary Artery Disease
Disease Progression
Female
Humans
Male
Middle Aged
Myocardial Ischemia
Prognosis

Substances

Biomarkers

Grants and funding

221100310100/The Major Science and Technology projects of Henan Province