Australasian recurrent pregnancy loss clinical management guideline 2024, part II

Adriana Suker; Ying Li; Danielle Robson; Anthony Marren; Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) Group

doi:10.1111/ajo.13820

Australasian recurrent pregnancy loss clinical management guideline 2024, part II

Aust N Z J Obstet Gynaecol. 2024 Jun 27. doi: 10.1111/ajo.13820. Online ahead of print.

Authors

Adriana Suker¹, Ying Li², Danielle Robson², Anthony Marren²; Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) Group

Collaborators

Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) Group:
Rob Norman, Gab Kovacs, Lucy Prentice, Elizabeth Glanville, Leigh Searle, Olivia Stuart, Vicki Nisenblat, Neil Johnson, Yousif Alyousif, Maree Lee, Kate Burston, Michael Chapman, L Sebastian, Phill McChessney, Clare Boothroyd, Neerja Kamal, Anne Clark, Violet Kieu, Rituparna Dutta, Lynn Burmeister, Ashleigh Smith, Louise Hull, Vamsee Thalluri, Giselle Crawford, Beverley Vollenhoven Sarah Hunt, Nicole Hope, Sameer Jakar, Seema Mohiuddin, Fleur Cattrall, Peter Leung, Roger Hart, Alison Gee, Katrina Rowan, Michele Kwik, Iris Wang, Jinny Foo, Rabia Shaik, Tamara Hunter, Nalini Gayer, Raelia Lew, Rebecca Mackenzie-Proctor, Anusch Yazdani, Rob Lahoud, Cheryl Phua, Shannon Zawada, Gabrielle Dezarnaulds, Sonal Karia, Devini Ameratunga, Vanessa Ross, Manny Mangat, Raewyn Tierney, Shadi Khashaba, David Greening, Janelle McDonald, Myvanwy McAveen

Affiliations

¹ Department of Obstetrics and Gynaecology, Liverpool Hospital, Sydney, New South Wales, Australia.
² Department of Reproductive Endocrinology and Infertility, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

PMID: 38934293
DOI: 10.1111/ajo.13820

Abstract

Part II of the Australasian guideline for the investigation and management of recurrent pregnancy loss (RPL) provides evidence-based guidance on the management of RPL provided. The implications of inherited and acquired thrombophilia with respect to RPL and suggestions for clinical management are provided. Autoimmune factors, including human leukocyte antigen, cytokines, antinuclear antibodies and coeliac antibodies, and guidance for management are discussed. Infective, inflammatory and endometrial causes of RPL are discussed in detail. Environmental and lifestyle factors, male factor and unexplained causes are outlined. Levels of evidence and grades of consensus are provided for all evidence-based statements.

Keywords: RPL; guideline; recurrent miscarriage; recurrent pregnancy loss.

© 2024 The Author(s). Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists.