Ocular side effects of anticancer agents used in the treatment of gynecologic cancers

Gynecol Oncol. 2024 Sep:188:147-157. doi: 10.1016/j.ygyno.2024.06.003. Epub 2024 Jul 4.

Abstract

The treatment landscape of gynecologic cancers has expanded in recent years to include targeted and immune-based therapies. These therapies often have ocular side effects not seen with conventional chemotherapies, some of which can cause significant visual impairment if not recognized in a timely fashion. Clinicians must know how to appropriately identify, mitigate, and treat these ocular adverse events. Management often involves working with an interdisciplinary team of eye specialists, and it is important to know when to refer patients for specialized care. Proactive identification of eye specialists, especially in rural and community settings where access to care can be limited, may be necessary. Here, we discuss the management of common ocular toxicities seen with novel anticancer agents used to treat gynecologic cancers.

Keywords: Ocular side effects; Targeted therapies; Treatment toxicity.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents* / adverse effects
  • Eye Diseases / chemically induced
  • Female
  • Genital Neoplasms, Female* / drug therapy
  • Humans

Substances

  • Antineoplastic Agents