Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic

Affiliations

• ¹ CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
• ² Changping Laboratory, Beijing, China.
• ³ Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
• ⁴ Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK. [email protected].
• ⁵ University of Chinese Academy of Sciences, Beijing, China.
• ⁶ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.
• ⁷ Joint Graduate Program of Peking-Tsinghua-NIBS, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
• ⁸ Changping Laboratory, Beijing, China. [email protected].
• ⁹ Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. [email protected].
• ¹⁰ Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK. [email protected].
• ¹¹ Changping Laboratory, Beijing, China. [email protected].
• ¹² Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. [email protected].
• ¹³ Joint Graduate Program of Peking-Tsinghua-NIBS, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. [email protected].
• ¹⁴ CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. [email protected].
• ¹⁵ Changping Laboratory, Beijing, China. [email protected].
• ¹⁶ University of Chinese Academy of Sciences, Beijing, China. [email protected].