The epoxide hydratase inducer trans-stilbene oxide shifts the metabolic epoxidation of benzo(a)pyrene from the bay- to the K-region and reduces its mutagenicity

Mol Pharmacol. 1979 Sep;16(2):656-66.
No abstract available

MeSH terms

  • Animals
  • Benzopyrenes / metabolism*
  • Chemical Phenomena
  • Chemistry
  • Enzyme Induction / drug effects
  • Epoxide Hydrolases / biosynthesis*
  • In Vitro Techniques
  • Male
  • Mixed Function Oxygenases / metabolism
  • Mutagens / metabolism*
  • Rats
  • Salmonella typhimurium / genetics
  • Stilbenes / pharmacology*

Substances

  • Benzopyrenes
  • Mutagens
  • Stilbenes
  • Mixed Function Oxygenases
  • Epoxide Hydrolases