Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration

Claudia Traidl-Hoffmann; Jamie Afghani; Cezmi A Akdis; Mübecel Akdis; Handan Aydin; Katja Bärenfaller; Heidrun Behrendt; Thomas Bieber; Paul Bigliardi; Mei Bigliardi-Qi; Charlotte Menné Bonefeld; Stefanie Bösch; Marie Charlotte Brüggen; Sebastian Diemert; Hans-Werner Duchna; Martina Fähndrich; Danielle Fehr; Marc Fellmann; Remo Frei; Lena H Garvey; Raschid Gharbo; Mehmet Gökkaya; Karin Grando; Carole Guillet; Erman Guler; Jan Gutermuth; Nadine Herrmann; Dirk Jan Hijnen; Claudia Hülpüsch; Alan D Irvine; Erika Jensen-Jarolim; Heidi H Kong; Hillel Koren; Claudia C V Lang; Roger Lauener; Laura Maintz; Pierre-Yves Mantel; Emanuel Maverakis; Matthias Möhrenschlager; Svenja Müller; Kari Nadeau; Avidan U Neumann; Liam O'Mahony; Fahafahantsoa Rapelanoro Rabenja; Harald Renz; Claudio Rhyner; Ernst Rietschel; Johannes Ring; Caroline Roduit; Mari Sasaki; Mirjam Schenk; Jens Schröder; Dagmar Simon; Hans-Uwe Simon; Milena Sokolowska; Sonja Ständer; Martin Steinhoff; Doris Straub Piccirillo; Alain Taïeb; Roberto Takaoka; Martin Tapparo; Henrique Teixeira; Jacob Pontoppidan Thyssen; Stephan Traidl; Miriam Uhlmann; Willem van de Veen; Marianne van Hage; Christian Virchow; Andreas Wollenberg; Mitamura Yasutaka; Alexander Zink; Peter Schmid-Grendelmeier

doi:10.1111/all.16247

Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration

Allergy. 2024 Oct;79(10):2605-2624. doi: 10.1111/all.16247. Epub 2024 Aug 4.

Authors

Claudia Traidl-Hoffmann^{1

2

3}, Jamie Afghani¹, Cezmi A Akdis^{3

4}, Mübecel Akdis⁴, Handan Aydin⁵, Katja Bärenfaller⁴, Heidrun Behrendt⁶, Thomas Bieber^{3

7}, Paul Bigliardi⁸, Mei Bigliardi-Qi⁸, Charlotte Menné Bonefeld⁹, Stefanie Bösch^{10

11}, Marie Charlotte Brüggen^{3

10

11}, Sebastian Diemert¹², Hans-Werner Duchna^{3

13}, Martina Fähndrich¹⁴, Danielle Fehr^{3

10

11}, Marc Fellmann¹⁵, Remo Frei^{3

16

17}, Lena H Garvey^{18

19}, Raschid Gharbo²⁰, Mehmet Gökkaya^{1

2}, Karin Grando^{3

10

11}, Carole Guillet^{10

11}, Erman Guler²¹, Jan Gutermuth²², Nadine Herrmann²³, Dirk Jan Hijnen²⁴, Claudia Hülpüsch^{1

2

3}, Alan D Irvine²⁵, Erika Jensen-Jarolim^{26

27}, Heidi H Kong²⁸, Hillel Koren²⁹, Claudia C V Lang^{3

9

10}, Roger Lauener³⁰, Laura Maintz²³, Pierre-Yves Mantel³, Emanuel Maverakis³¹, Matthias Möhrenschlager¹³, Svenja Müller²³, Kari Nadeau³², Avidan U Neumann^{1

2}, Liam O'Mahony^{33

34}, Fahafahantsoa Rapelanoro Rabenja³⁵, Harald Renz³⁶, Claudio Rhyner³, Ernst Rietschel³, Johannes Ring³⁷, Caroline Roduit^{16

30}, Mari Sasaki¹⁶, Mirjam Schenk^{3

38}, Jens Schröder³⁹, Dagmar Simon⁴⁰, Hans-Uwe Simon^{41

42}, Milena Sokolowska^{3

4}, Sonja Ständer⁴³, Martin Steinhoff^{44

45

46

47

48

49

50}, Doris Straub Piccirillo³, Alain Taïeb⁵¹, Roberto Takaoka⁵², Martin Tapparo⁵³, Henrique Teixeira²², Jacob Pontoppidan Thyssen⁵⁴, Stephan Traidl^{55

56}, Miriam Uhlmann³, Willem van de Veen⁴, Marianne van Hage⁵⁷, Christian Virchow⁵⁸, Andreas Wollenberg^{59

60

61}, Mitamura Yasutaka⁴, Alexander Zink^{62

63}, Peter Schmid-Grendelmeier^{3

9

10}

Affiliations

¹ Institute of Environmental Medicine and Integrative Health, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
² Institute of Environmental Medicine, Helmholtz Zentrum München, Augsburg, Germany.
³ Christine Kühne-Center for Allergy Research and Education (CK-CARE), Medicine Campus, Davos, Switzerland.
⁴ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland.
⁵ AbbVie Inc., North Chicago, Illinois, USA.
⁶ Center for Allergy and Environment (ZAUM), Technische Universität München, Germany.
⁷ Davos Biosciences, Davos, Switzerland.
⁸ University of Minnesota, Minneapolis, Minnesota, USA.
⁹ Department of Immunology and Microbiology, The LEO Foundation Skin Immunology Research Center, University of Copenhagen, Copenhagen, Denmark.
¹⁰ Department of Dermatology, Allergy Unit, University Hospital of Zürich, Zürich, Switzerland.
¹¹ Faculty of Medicine, University of Zürich, Zürich, Switzerland.
¹² Almirall Hermal GmbH, Reinbek, Germany.
¹³ Hochgebirgsklinik Davos, Davos, Switzerland.
¹⁴ LEO Pharmaceutical Products Sarath Ltd, Zürich, Switzerland.
¹⁵ Pfizer Switzerland AG, Zürich, Switzerland.
¹⁶ Department of Pediatrics, Division of Respiratory Medicine and Allergology, Bern University Hospital, Bern, Switzerland.
¹⁷ Department of BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
¹⁸ Department of Dermatology and Allergy, Allergy Clinic, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
¹⁹ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
²⁰ Psychosomatic Department, Hochgebirgsklinik, Davos, Switzerland.
²¹ Pfizer, Istanbul, Turkey.
²² Universitair Ziekenhuis, Brussel, Belgium.
²³ Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
²⁴ Diakonessenhuis Utrecht Zeist Doorn Locatie Utrecht, Erasmus MC, University Medical Center Utrecht, Utrecht, Netherlands.
²⁵ Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.
²⁶ Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
²⁷ The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
²⁸ Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
²⁹ Environmental Health, LLC, Durham, North Carolina, USA.
³⁰ Ostschweizer Kinderspital St. Gallen, St.Gallen, Switzerland.
³¹ Department of Dermatology, University of California Davis, Sacramento, California, USA.
³² Stanford University School of Medicine, Stanford, California, USA.
³³ APC Microbiome Ireland, University College Cork, Cork, Ireland.
³⁴ Department of Medicine and School of Microbiology, University College Cork, Cork, Ireland.
³⁵ Faculty of Médicine, Antananarivo, Madagascar.
³⁶ Institute of Laboratory Medicine, Philipps University, Marburg, Germany.
³⁷ Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Munich, Germany.
³⁸ Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.
³⁹ Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein (UK-SH), Kiel, Germany.
⁴⁰ Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁴¹ Institute of Pharmacology, University of Bern, Bern, Switzerland.
⁴² Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany.
⁴³ Center for Chronic Pruritus and Department of Dermatology, University Hospital Münster, Münster, Germany.
⁴⁴ Department of Dermatology and Venereology, Hamad Medical Corporation, Doha, Qatar.
⁴⁵ Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
⁴⁶ Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
⁴⁷ School of Medicine, Weill Cornell Medicine-Qatar, Ar-Rayyan, Qatar.
⁴⁸ College of Medicine, Qatar University, Doha, Qatar.
⁴⁹ College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
⁵⁰ Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.
⁵¹ INSERM 1312, University of Bordeaux, Bordeaux, France.
⁵² Department of Dermatology, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
⁵³ Bencard Allergie GmbH München, Munich, Germany.
⁵⁴ Department of Dermatology and Venerology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
⁵⁵ Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
⁵⁶ Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.
⁵⁷ Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institute and Karolinska University Hospital Stockholm, Solna, Sweden.
⁵⁸ Department of Pneumology, Intensive Care Medicine, Center for Internal Medicine, Universitätsmedizin Rostock, Rostock, Germany.
⁵⁹ Department of Dermatology and Allergy, Ludwig-Maximilian-University, Munich, Germany.
⁶⁰ Department of Dermatology and Allergy, University Hospital Augsburg, Augsburg, Germany.
⁶¹ Comprehensive Center of Inflammation Medicine, University Hospital Schleswig Holstein Campus Luebeck, Lubeck, Germany.
⁶² Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany.
⁶³ Department of Medicine Solna, Division of Dermatology and Venereology, Karolinska Institutet, Stockholm, Sweden.

PMID: 39099205
DOI: 10.1111/all.16247

Abstract

The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical aspects of AD, including neuroimmunology, environmental factors, comorbidities, and breakthroughs in prevention, diagnosis, and treatment. The discussions were geared towards fostering a collaborative approach to integrate these advancements into practical, patient-centric care. The forum underlined the mounting burden of AD, attributing it to significant environmental and lifestyle changes. It acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy. The 4th Davos Declaration marks a significant milestone in the journey to improve care for people with AD. By promoting a holistic approach that combines research, education, and clinical application, the Forum sets a roadmap for stakeholders to collaborate to improve patient outcomes in AD, reflecting a commitment to adapt and respond to the dynamic challenges of AD in a changing world.

Keywords: allergy treament; atopic dermatitis; barrier; environment; hygiene hypothesis.

Publication types

Review

MeSH terms

Dermatitis, Atopic* / therapy
Disease Management
Humans