Blood Pressure Time in Target Range and its Impact on Clinical Outcomes

Curr Cardiol Rep. 2024 Oct;26(10):1145-1151. doi: 10.1007/s11886-024-02111-9. Epub 2024 Aug 14.

Abstract

Purpose of review: To examine the concept of time in target range for blood pressure (BP) management, exploring its calculation methods, implications for patient outcomes, and potential use in patient care.

Recent findings: Recent post-hoc analyses of clinical trials and observational studies highlight the importance of BP time in target range in predicting cardiovascular outcomes. Higher time in target range correlates with reduced risks of major adverse cardiovascular events including heart failure, stroke, myocardial infarction and all-cause mortality. Additionally, longer time in target range decreases the risk of incident atrial fibrillation and risk of developing dementia. BP time in target range is a novel metric offering valuable insights into BP control and its impact on clinical outcomes. Higher time in target range is consistently associated with better cardiovascular outcomes across various patient populations. However, the clinical application of BP time in target range requires further investigation through prospective clinical trials and real-world studies. Integrating wearable devices for continuous BP monitoring could enhance the practical utility of BP time in target range in hypertension management.

Keywords: Cardiovascular disease; Cardiovascular disease prevention; Cardiovascular outcomes; Hypertension; Time in target range; Time in therapeutic range.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents* / therapeutic use
  • Blood Pressure Determination / methods
  • Blood Pressure Monitoring, Ambulatory
  • Blood Pressure*
  • Cardiovascular Diseases
  • Humans
  • Hypertension* / drug therapy
  • Hypertension* / physiopathology
  • Time Factors

Substances

  • Antihypertensive Agents