Sepsis-Induced Coagulopathy Score is Associated with an Increased Risk of New-Onset Atrial Fibrillation in Septic Patients: A Two-Centered Retrospective Study

Juan Li; Shu Wang; Chaoping Ma; Ning Ning; Yingying Huang; Min Jiao; Jiyuan Zhang; Wenwu Sun; Jiaoyan Li; Bing Zhao; Enqiang Mao; Zaiqian Che; Chengjin Gao

doi:10.2147/JIR.S467424

Sepsis-Induced Coagulopathy Score is Associated with an Increased Risk of New-Onset Atrial Fibrillation in Septic Patients: A Two-Centered Retrospective Study

J Inflamm Res. 2024 Aug 30:17:5889-5899. doi: 10.2147/JIR.S467424. eCollection 2024.

Authors

Juan Li^#¹, Shu Wang^#², Chaoping Ma^#¹, Ning Ning^#³, Yingying Huang^#^{1

4}, Min Jiao¹, Jiyuan Zhang¹, Wenwu Sun³, Jiaoyan Li³, Bing Zhao³, Enqiang Mao³, Zaiqian Che³, Chengjin Gao¹

Affiliations

¹ Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
² Department of Intensive Care Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400016, People's Republic of China.
³ Departments of Emergency, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, People's Republic of China.
⁴ Dementia Research Center, Macquarie University, Sydney, Australia.

^# Contributed equally.

Abstract

Purpose: New-onset atrial fibrillation (NOAF) and sepsis-induced coagulopathy (SIC) are severe complications in septic patients. However, the relationship between NOAF and SIC score has not been clearly defined. This study aims to investigate the association between SIC score and NOAF, as well as their effect on mortality in sepsis.

Patients and methods: This study was a two-center retrospective analysis. Medical data were collected from patients diagnosed with sepsis. The patients were divided into NOAF and non-NOAF groups, and the SIC score was calculated for each group. Univariable and multivariable logistic regression analyses were performed to explore the relationship between the SIC score and NOAF, as well as their effects on mortality. The Kaplan-Meier curve was used to assess the survival rate.

Results: A total of 2,280 septic patients were included, with 132 (5.7%) suffering from NOAF. Multivariable logistic regression analyses indicated that age, gender, the Acute Physiology and Chronic Health Evaluation II score (APACHE II), heart rate, renal failure, stroke, chronic obstructive pulmonary disease (COPD), and the SIC score were independent risk factors for NOAF in sepsis. Moreover, NOAF was associated with an increased risk of in-hospital mortality, 28-day mortality, and 90-day mortality. These results were consistent across subgroup analyses.

Conclusion: The SIC score was an independent risk factor for NOAF in septic patients, and NOAF was an independent risk factor for predicting mortality.

Keywords: association; mortality; new-onset atrial fibrillation; sepsis; sepsis-induced coagulopathy.

Grants and funding

This research was supported by Medical Innovation Research Project of Shanghai Science and Technology Commission (No. 23Y31900102); Key Supporting Subject Researching Project of Shanghai Municipal Health Commission (No. 2023ZDFC0106); National Natural Science Foundation of China (No. 82172138) and Innovation Research Project of Shanghai Science and Technology Commission (No. 21Y11902400).