Management of Cancer Therapy-Related Cardiac Dysfunction: A Case-Based Review

Am J Cardiol. 2024 Nov 15:231:20-31. doi: 10.1016/j.amjcard.2024.08.029. Epub 2024 Sep 2.

Abstract

With an ever-expanding repertoire of cancer therapies, cardiologists increasingly encounter patients with cancer therapy-related cardiac dysfunction. This can range from asymptomatic mild left ventricular dysfunction to severe symptomatic congestive heart failure. A multidisciplinary approach involving oncologists and cardiologists is needed in the management of these patients. This case-based review provides a practical guide for clinicians regarding the diagnosis and management of cancer therapy-related cardiac dysfunction associated with commonly used cancer treatments: anthracyclines, human epidermal receptor 2-targeted therapies, and immune checkpoint inhibitors.

Keywords: cardio-oncology; cardiotoxicity.

Publication types

  • Review

MeSH terms

  • Anthracyclines / adverse effects
  • Antineoplastic Agents* / adverse effects
  • Cardiotoxicity / diagnosis
  • Cardiotoxicity / etiology
  • Cardiotoxicity / physiopathology
  • Cardiotoxicity / therapy
  • Heart Failure* / chemically induced
  • Heart Failure* / diagnosis
  • Heart Failure* / physiopathology
  • Heart Failure* / therapy
  • Humans
  • Immune Checkpoint Inhibitors / adverse effects
  • Neoplasms / complications
  • Neoplasms / drug therapy
  • Ventricular Dysfunction, Left* / chemically induced
  • Ventricular Dysfunction, Left* / diagnosis
  • Ventricular Dysfunction, Left* / physiopathology
  • Ventricular Dysfunction, Left* / therapy

Substances

  • Anthracyclines
  • Antineoplastic Agents
  • Immune Checkpoint Inhibitors