Proton therapy for breast cancer: Reducing toxicity

Thorac Cancer. 2024 Oct;15(30):2156-2165. doi: 10.1111/1759-7714.15451. Epub 2024 Sep 14.

Abstract

Radiotherapy is a crucial component in the holistic management of breast cancer, with approximately 60% of individuals diagnosed with breast cancer requiring this treatment. As the survival rate of individuals with breast cancer has significantly increased, there is a growing focus on the long-term well-being of patients. Proton therapy (PT) is a new and rapidly developing radiotherapy method. In comparison with conventional photon therapy, PT offers the benefits of decreased radiation toxicity and increased dosage in the designated region. This can extend patients' lifespan and enhance their overall well-being. The present analysis examines the function of PT in diminishing the harmful effects of radiation in cases of breast cancer, while also providing a brief overview of the future potential and obstacles associated with PT for breast cancer.

Keywords: breast cancer; cardiotoxicity; organs at risk; proton therapy; pulmonary toxicity.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms* / radiotherapy
  • Female
  • Humans
  • Proton Therapy* / adverse effects
  • Proton Therapy* / methods