Virologic failure of long-acting rilpivirine/cabotegravir is rare but may result in severely limited treatment options. Known risk factors cannot predict all cases. Therapeutic drug monitoring (TDM) may help identify patients at risk, but reliable thresholds are missing. We report retrospective TDM in a cohort of 5 patients, including 1 virological failure.
Keywords: TDM; cabotegravir; rilpivirine; two-class resistance; virologic failure.
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.